The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/hepatitis C virus coinfected patients
| Autor: | Adriana Camargo Ferrasi, Liciana Vaz de Arruda Silveira, Maria Inês de Moura Campos Pardini, Alexandre Naime Barbosa, Natália Picelli, Giovanni Faria Silva, Aline Aki Tanikawa, Rejane Maria Tommasini Grotto |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Liver Cirrhosis Male Microbiology (medical) lcsh:Arctic medicine. Tropical medicine Genotype lcsh:RC955-962 Hepacivirus Hepatitis C virus Liver fibrosis HIV Infections medicine.disease_cause Virus Fibrosis medicine Humans Antigens Human Platelet Polymorphism Genetic biology Human immunodeficiency virus Coinfection Hepatitis C Hepatitis C Chronic Human immunodeficiency vírus medicine.disease biology.organism_classification Human platelet antigen Infectious Diseases Immunology Disease Progression HIV-1 biology.protein Parasitology Hepatitis C vírus Hepatic fibrosis |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical v.48 n.4 2015 Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Revista da Sociedade Brasileira de Medicina Tropical, Volume: 48, Issue: 4, Pages: 406-409, Published: AUG 2015 Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 4, Pp 406-409 (2015) |
| ISSN: | 1678-9849 0037-8682 |
| DOI: | 10.1590/0037-8682-0152-2015 |
| Popis: | Made available in DSpace on 2018-12-11T16:58:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-07-01. Added 1 bitstream(s) on 2019-10-09T18:29:56Z : No. of bitstreams: 1 S0037-86822015000400406.pdf: 721757 bytes, checksum: 3d3536e15d8fcf0f0f23a39db4f03177 (MD5) Introduction: Hepatic fibrosis progression in patients with chronic hepatitis C virus infections has been associated with viral and host factors, including genetic polymorphisms. Human platelet antigen polymorphisms are associated with the rapid development of fibrosis in HCV-monoinfected patients. This study aimed to determine whether such an association exists in human immunodeficiency virus-1/hepatitis C virus-coinfected patients. Methods: Genomic deoxyribonucleic acid from 36 human immunodeficiency virus-1/hepatitis C virus-coinfected patients was genotyped to determine the presence of human platelet antigens-1, -3, or -5 polymorphisms. Fibrosis progression was evaluated using the Metavir scoring system, and the patients were assigned to two groups, namely, G1 that comprised patients with F1, portal fibrosis without septa, or F2, few septa (n = 23) and G2 that comprised patients with F3, numerous septa, or F4, cirrhosis (n = 13). Fisher’s exact test was utilized to determine possible associations between the human platelet antigen polymorphisms and fibrosis progression. Results: There were no deviations from the Hardy-Weinberg equilibrium in the human platelet antigen systems evaluated. Statistically significant differences were not observed between G1 and G2 with respect to the distributions of the allelic and genotypic frequencies of the human platelet antigen systems. Conclusions: The greater stimulation of hepatic stellate cells by the human immunodeficiency virus and, consequently, the increased expression of transforming growth factor beta can offset the effect of human platelet antigen polymorphism on the progression of fibrosis in patients coinfected with the human immunodeficiency virus-1 and the hepatitis C virus. Laboratório de Biologia Molecular do Hemocentro Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP Departamento de Bioprocessos e Biotecnologia Fazenda Experimental Lageado Universidade Estadual Paulista “Júlio de Mesquita Filho”- UNESP Departamento de Clínica Médica Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP Departamento de Doenças Tropicais Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP Departamento de Bioestatística Instituto de Biociências de Botucatu Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP Laboratório de Biologia Molecular do Hemocentro Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP Departamento de Bioprocessos e Biotecnologia Fazenda Experimental Lageado Universidade Estadual Paulista “Júlio de Mesquita Filho”- UNESP Departamento de Clínica Médica Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP Departamento de Doenças Tropicais Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP Departamento de Bioestatística Instituto de Biociências de Botucatu Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP |
| Databáze: | OpenAIRE |
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