Hemoglobin Rainier (β 145 Tyrosine → Histidine): Alkali-Resistant Hemoglobin with Increased Oxygen Affinity

histidine). Hemoglobin Rainier is the first example of a single amino acid substitution in adult human hemoglobin, causing increased resistance to alkali denaturation. -->

ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.159.3816.741
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2facc353fdc27da0f32671e74680be https://doi.org/10.1126/science.159.3816.741
Přírůstkové číslo:	edsair.doi.dedup.....7c2facc353fdc27da0f32671e74680be
Autor:	George Stamatoyannopoulos, Sigrid Heinenberg, Akira Yoshida, John W. Adamson
Rok vydání:	1968
Předmět:	Multidisciplinary Biochemistry Increased oxygen affinity Hemoglobin variants Hemoglobin Rainier Denaturation (biochemistry) Hemoglobin Tyrosine Biology Alkali-resistant hemoglobin Histidine
Zdroj:	Science. 159:741-743
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.159.3816.741
Popis:	Hemoglobin Rainier, a new hemoglobin variant associated with erythrocytosis, was found in six members of a Caucasiant family. Structurally, it represents substitution of histidine for the invariant residute H23 tyrosine in the beta-hemoglobin polypeptide chain (beta(145) tyrosine --> histidine). Hemoglobin Rainier is the first example of a single amino acid substitution in adult human hemoglobin, causing increased resistance to alkali denaturation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2facc353fdc27da0f32671e74680be https://doi.org/10.1126/science.159.3816.741 Zobrazit plný text záznamu