A hemodynamic network involving the insula, the cingulate, and the basal forebrain correlates with EEG synchronization phases of sleep instability
| Autor: | Louis Lemieux, Vasileios Kokkinos, George K. Kostopoulos, Serge Vulliemoz, Kyriakos Garganis, Michalis Koutroumanidis, Andreas M. Koupparis |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Basal Forebrain media_common.quotation_subject Polysomnography Insula Cyclic alternating pattern Electroencephalography EEG-fMRI Non-rapid eye movement sleep Basal forebrain 03 medical and health sciences 0302 clinical medicine Physiology (medical) Medicine Cingulate Humans Wakefulness media_common medicine.diagnostic_test business.industry Hemodynamics Eye movement Brain Waves Magnetic Resonance Imaging ddc:616.8 030228 respiratory system Female Neurology (clinical) Sleep Stages business Functional magnetic resonance imaging Sleep Neuroscience 030217 neurology & neurosurgery Vigilance (psychology) |
| Zdroj: | Sleep, Vol. 42, No 4 (2019) pp. 1-8 |
| ISSN: | 1550-9109 0161-8105 |
| Popis: | The cyclic alternating pattern (CAP) encompasses the pseudoperiodic appearance of synchronized brain waves and rhythms and is considered a regulator of the nonrapid eye movement (NREM) sleep vigilance level, reflecting sleep instability. To determine the brain regions responsible for this phenomenon, we scored and analyzed sleep functional magnetic resonance imaging data acquired with simultaneous electroencephalography (EEG-fMRI). Group analysis revealed a set of brain areas showing statistically significant blood oxygen-level dependent signal correlated positively with the synchronization phase of the CAP, most prominent being the insula, the middle cingulate gyrus, and the basal forebrain. These areas may form a network acting as a synchronization pacemaker, controlling the level of NREM sleep vigilance and the sleeper's arousability. |
| Databáze: | OpenAIRE |
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