Measuring abnormal intrinsic brain activities in patients with retinal detachment using amplitude of low-frequency fluctuation: a resting-state fMRI study
| Autor: | Yi Shao, Qiong Zhou, Lei Ye, Lin Yang, Hong-Hua Kang, Dan Li, Yong-Qiang Shu, Qing-Hai Li, You-Lan Min, Pei-Wen Zhu |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Brain activity and meditation Low frequency 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance medicine Humans Visual Pathways In patient Physics Brain Mapping Resting state fMRI medicine.diagnostic_test General Neuroscience Retinal Detachment Brain Retinal detachment General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging 030104 developmental biology Amplitude ROC Curve Female Functional magnetic resonance imaging human activities 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Neuroscience. 129:681-686 |
| ISSN: | 1543-5245 0020-7454 |
| Popis: | The targets of this study were to access the alternations of spontaneous brain activity in RD patients by amplitude of low-frequency fluctuation (ALFF) method and to explore their relationships with clinical behavioral performance.A total of 20 patients with RD (6 males and 14 females), and 20 healthy controls (HCs) (6 males and 14 females) were recruited, and were matched in sex and age. All participants finished the functional magnetic resonance imaging (fMRI) scanning. We applied the ALFF method to detect the spontaneous brain activity. Receiver operating characteristic (ROC) curve was applied to distinguish RD Patients from HCs.RD patients showed decreased ALFF values in the right occipital lobe and right medial frontal gyrus and increased ALFF values in the right frontal superior orbital and left inferior temporal gyrus when compared with HCs. In RD patients, we did not find any relationship between the mean ALFF values and the clinical behavioral performances.The RD patients exhibited abnormal spontaneous brain activity in vision and vision related brain regions, which might explore potential pathological mechanism of acute vision loss in RD patients. |
| Databáze: | OpenAIRE |
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