Can preoperative modified systemic inflammation score (mSIS) be used to predict malignancy in persistent nondiagnostic thyroid nodules?
| Autor: | Hakan Ataş, Birol Korukluoğlu, Barış Saylam, Bülent Çomçalı, Mesut Tez, Neşe Yakşi |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Thyroid nodules medicine.medical_specialty Risk of malignancy medicine.medical_treatment Biopsy Fine-Needle Malignancy Systemic inflammation Gastroenterology Article Systemic inflammation score Internal medicine lymphocyte to monocyte ratio medicine Humans nondiagnostic In patient Thyroid Neoplasms Thyroid Nodule Low lymphocyte count Aged Retrospective Studies Aged 80 and over Inflammation business.industry thyroid nodules Thyroid Thyroidectomy General Medicine Middle Aged medicine.disease medicine.anatomical_structure Female medicine.symptom business malignancy |
| Zdroj: | Turkish Journal of Medical Sciences |
| ISSN: | 1303-6165 |
| DOI: | 10.3906/sag-2011-177 |
| Popis: | Background/aim Despite the use of ultrasound guidance, a significant part of thyroid biopsies are nondiagnostic (ND). We aimed to investigate the utility of the preoperative modified systemic inflammation score (mSIS) to predict malignancies in patients with persistent ND thyroid nodules (TNs). Materials and methods Records of 924 patients underwent thyroidectomy between September 2016 and May 2019 were retrospectively reviewed. The calculation of mSIS was as follows: mSIS 0 [patients with albumin (ALB) ≥ 4.0 g/dL and lymphocyte to monocyte ratio (LMR) ≥ 3.4], mSIS 1 [ALB < 4.0 g/dL or LMR < 3.4], and mSIS 2 [ALB < 4.0 g/dL and LMR < 3.4]. Results One hundred and thirty-six patients were included in the study. Of the patients with a median age of 49 (21–81) years, 26 (19.1%) were male, and 110 (80.9%) were female. Besides low lymphocyte count (P = 0.03), and ALB levels (P < 0.01), higher BMI (P = 0.02) were also associated with malignancy. In patients classified as mSIS 2, 1 and 0; malignancy rates were 100%, 25.8%, and 16.1%, respectively. The association between preoperative mSIS and thyroid malignancies was statistically significant (P < 0.01). Conclusion We recommend that when patients with persistent ND TNs are assigned to mSIS 2 or 1, surgery should not be delayed due to the risk of malignancy. |
| Databáze: | OpenAIRE |
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