Electrophoretic analysis of enzyme-linked immunoglobulins and their clinical significance

Autor:	Tatsuo Tozawa
Rok vydání:	1991
Předmět:	Electrophoresis chemistry.chemical_classification Chromatography biology medicine.diagnostic_test Chemistry Stereochemistry Binding protein General Chemistry Immunoelectrophoresis Immunoglobulin E Isozyme Enzyme assay Autoimmune Diseases Enzymes Isoenzymes Enzyme Biochemistry biology.protein medicine Humans Clinical significance Antibody Autoantibodies
Zdroj:	Journal of Chromatography B: Biomedical Sciences and Applications. 569:347-365
ISSN:	0378-4347
Popis:	The appearance of circulating enzyme-linked immunoglobulin complexes (EIg) is common for most enzymes used in clinical biochemical tests. The presence of EIg may result in altered enzyme activity in serum and interfere with the measurement of isoenzymes, and is thus of diagnostic importance. EIg can be identified by confirming that the binding protein is an immunoglobulin by its reaction with specific anti-human immunoglobulin antibodies. Currently, the presence of EIg in an individual is regarded as a benign phenomenon, not indicative of any particular disease process. However, it is becoming clear that EIgG are closely associated with autoimmune states.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2b594518403cfe9c6c5ff2888c92c1 https://doi.org/10.1016/0378-4347(91)80237-7 Zobrazit plný text záznamu