Recalcitrant psoriasiform dermatosis of the face: Is it related to pityriasis rubra pilaris?

Autor:	Chee-Leok Goh, Siong See Joyce Lee, Emily Yiping Gan, See Ket Ng
Rok vydání:	2018
Předmět:	Adult Male Treatment response Pathology medicine.medical_specialty Histology Adolescent Biopsy Hyperkeratosis Dermatology Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Parakeratosis Retrospective Studies integumentary system business.industry Acantholysis Psoriasiform plaques Middle Aged medicine.disease Chin Cross-Sectional Studies medicine.anatomical_structure 030220 oncology & carcinogenesis Pityriasis Rubra Pilaris Female Pityriasis rubra pilaris medicine.symptom business Facial Dermatoses
Zdroj:	Journal of Cutaneous Pathology. 45:491-497
ISSN:	0303-6987
DOI:	10.1111/cup.13148
Popis:	Background There are patients with recalcitrant psoriasiform plaques that do not fit into conventional categories of facial dermatoses. Our study aims to describe the clinicopathological characteristics of several patients with a unique presentation of persistent psoriasiform facial rashes. Methods This retrospective cross-sectional study analyzed clinical and histological data of known cases of recalcitrant psoriasiform dermatosis of the face diagnosed at National Skin Centre, Singapore, over 10 years. Results There were 8 Chinese patients with mean age at onset of 29 years. Majority had pink to pink-orange well-defined plaques with dry scale (n = 6, 75%), distributed mostly on the cheeks (100%) and chin (n = 7, 88%). Hyperkeratosis, parakeratosis, preserved granular layer and psoriasiform hyperplasia were showed in all biopsies. Other common findings included subtle subcorneal acantholysis, "checkerboard" alternating ortho-/parakeratosis, vacuolated keratinocytes and follicular plugging. All patients showed little treatment response. One patient eventually developed features of type II pityriasis rubra pilaris (PRP). Our study was limited by its small sample size and lack of a pre-existing diagnostic code. Conclusions This recalcitrant psoriasiform facial dermatosis seems to be a distinct entity, with consistent and reproducible clinical features and a PRP-like histology, bearing some resemblance to the recently described condition-facial discoid dermatosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c28e41181146301df791055107f8bc7 https://doi.org/10.1111/cup.13148 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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