Impact of Preoperative MRI in Invasive Ductal Carcinoma With Lobular Features on Core Biopsy
| Autor: | Saba Bajwa, Soni Soumian, Sankaran Narayanan, Sekhar Marla, Mihir Chandarana, Zatinahhayu Mohd-Isa, Seema Salehi-Bird, Ghaleb Goussous, Lisette Hammond, Elizabeth Gunning, Sadaf Jafferbhoy |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Cancer Research medicine.medical_specialty medicine.medical_treatment Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer medicine Humans skin and connective tissue diseases Aged Neoplasm Staging Retrospective Studies medicine.diagnostic_test business.industry Carcinoma Ductal Breast Ultrasound Cancer Magnetic resonance imaging Histology Middle Aged medicine.disease Invasive ductal carcinoma Magnetic Resonance Imaging body regions Carcinoma Lobular 030104 developmental biology Oncology 030220 oncology & carcinogenesis Female Ultrasonography Mammary Radiology business Core biopsy Mastectomy |
| Zdroj: | Clinical Breast Cancer. 21:e194-e198 |
| ISSN: | 1526-8209 |
| DOI: | 10.1016/j.clbc.2020.08.007 |
| Popis: | Background Invasive breast cancer is comprised of a wide spectrum of histological types with different clinical presentations, imaging characteristics, and behaviors. Almost 10% of breast cancers with predominantly invasive ductal features have lobular components on core biopsy at primary diagnosis. Although the role of magnetic resonance imaging (MRI) in patients with purely lobular cancers is well-established, it is not clear if preoperative MRI is indicated in ductal cancer with lobular features. The aim of this study was to assess the role of preoperative MRI in patients with invasive ductal cancers with lobular features on core biopsy. Materials and Methods Data regarding patients with lobular features on core biopsy who underwent a preoperative MRI from January 2015 to December 2017 were retrospectively identified and analyzed. Imaging findings, additional investigations, and changes in treatment plans following the MRI scan were reviewed. Results The study included 120 patients, of whom 42 (35%) patients required a second-look ultrasound. Following a repeat ultrasound scan, 25 breasts and 4 axillae were biopsied. Thirty-eight percent of the breast biopsies and 50% of the axillary biopsies were malignant. Based on MRI findings, treatment plans changed in 22.5% of patients. MRI size was concordant with the histological size in 58.3% of cases, and MRI was accurate in 90% of patients in detecting multifocal disease requiring mastectomy. The majority of patients with changes in the management plans had mixed ductal and lobular cancer on final histology. Conclusion This study has demonstrated that MRI picks up additional malignancies and changes management plans in patients with lobular features on core biopsy and should be considered in the preoperative workup. |
| Databáze: | OpenAIRE |
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