A Community Perspective on the Inclusion of Pregnant Women in Tuberculosis Drug Trials
| Autor: | Kathryn Snow, Cynthia Lee, Dorothy Namutamba, Mike Frick, Marie Theunissen, Wim Vandevelde, Liani Smit, Suraj Madoori, Barbara Seaworth, Lindsay McKenna |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Tuberculosis Drug trial Research Subjects 030106 microbiology education Alternative medicine Community perspective Ethics Research 03 medical and health sciences 0302 clinical medicine Pregnancy Drug Discovery medicine Humans 030212 general & internal medicine Pregnancy Complications Infectious Psychiatry Research ethics business.industry medicine.disease Viewpoints Infectious Diseases Drug development Family medicine Female business Inclusion (education) |
| Popis: | Affecting both mother and the existing pregnancy, tuberculosis (TB) increases the likelihood of poor birth outcomes. Despite substantial clinical need for TB prevention and treatment, pregnant women remain neglected by research initiatives. As members of 3 community advisory boards that provide input into TB drug trials, we offer a community perspective on the inclusion of pregnant women in TB drug research and discuss (1) our perspective on the risk/benefit tradeoff of including pregnant women in research to address different forms of TB; (2) recent examples of progress in this area; (3) lessons learned from the human immunodeficiency virus research field, where pregnant women have enjoyed better-although imperfect-representation in research; and (4) recommendations for different stakeholders, including researchers, regulatory authorities, ethics committees, and policymakers. |
| Databáze: | OpenAIRE |
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