Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) screening among symptom-free healthcare workers
| Autor: | Steven D. Stovitz, Shalini L Kulasingam, Angela K. Ulrich, Louise C. Laurent, Pedro Belda-Ferre, Greg Humphrey, Clarisse Marotz, Ryan T. Demmer, Talia D. Wiggen, Ali J Strickland, Brianna M. Naumchik, Susan Kline, Peter De Hoff, Rob Knight |
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| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Epidemiology Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses Health Personnel medicine.disease_cause 01 natural sciences Medical and Health Sciences Virus Article Vaccine Related 03 medical and health sciences 0302 clinical medicine Clinical Research Biodefense Health care medicine Humans Mass Screening 030212 general & internal medicine 0101 mathematics Respiratory system skin and connective tissue diseases Lung Coronavirus business.industry Transmission (medicine) SARS-CoV-2 Prevention 010102 general mathematics Concise Communication fungi virus diseases COVID-19 Pneumonia Health Services Virology body regions Emerging Infectious Diseases Infectious Diseases Pneumonia & Influenza business Infection Delivery of Health Care |
| Zdroj: | Infection control and hospital epidemiology, vol 43, iss 5 Infection Control and Hospital Epidemiology medRxiv |
| Popis: | Importance: Current evidence suggests that transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is possible among symptom-free individuals but limited data are available on this topic in healthcare workers (HCW). The quality and acceptability of self-collected nasopharyngeal swabs (NPS) is unknown. Objective: To estimate the prevalence of SARS-CoV-2 infection and to assess the acceptability of self-collected NPS among HCW. Design: Cross-sectional convenience sample enrolled between April 20th and June 24th, 2020. We had >95% power to detect at least one positive test if the true underlying prevalence of SARS-CoV2 was > 1%. Setting: The metropolitan area surrounding Minneapolis and St. Paul, Minnesota. Participants: HCW free of self-reported upper respiratory symptoms were recruited. Exposures: Participants completed questionnaires regarding demographics, household characteristics, personal protective equipment (PPE) utilization and comorbidities. Outcomes: A participant self-collected nasopharyngeal swab (NPS) was obtained. SARS-CoV-2 infection was assessed via polymerase chain reaction. NPS discomfort was assessed on a scale of 1 (no discomfort) - 10 (extreme discomfort). NPS duration and depth into the nasopharynx, and willingness to perform future self-collections were assessed. Results: Among n=489 participants 80% were female and mean age+/-SD was 41+/-11. Participants reported being physicians (14%), nurse practitioners (8%), physicians assistants (4%), nurses (51%), medics (3%), or other which predominantly included laboratory technicians and administrative roles (22%). Exposure to a known/suspected COVID-19 case in the 14 days prior to enrollment was reported in 40% of participants. SARS-CoV-2 was not detected in any participant. The mean+/-SD discomfort level of the NPS was 4.5+/-2.0. 95% of participants reported that their self-swab was longer than or equal to the duration of patient swabs they had previously performed, and 89% reported the depth to be deeper than or equal to the depth of previous patient swabs. Over 95% of participants reported a willingness to repeat a self-collected NP swab in the future. Conclusions and Relevance: The point prevalence of SARS-CoV-2 infection was likely very low in symptom-free Minnesota healthcare workers from April 20th and June 24th, 2020. Self-collected NP swabs are well-tolerated and a viable alternative to provider-collected swabs to preserve PPE. |
| Databáze: | OpenAIRE |
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