An atlas of human metabolism
| Autor: | Jonathan L. Robinson, Jens Nielsen, Eduard J. Kerkhoven, Alex Hedin, L. Thomas Svensson, Lena Hansson, Bernhard O. Palsson, Virinchi Billa, Angelo Limeta, Pierre Etienne Cholley, Mathias Uhlén, Avlant Nilsson, Hao Wang, Adil Mardinoglu, Raphael Ferreira, Iván Domenzain, Mihail Anton, Daniel Cook, Pınar Kocabaş, Johan Gustafsson |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Future studies
Computer science Human metabolism Computational biology Biochemistry Article Omics data 03 medical and health sciences Human health 0302 clinical medicine SDG 3 - Good Health and Well-being Genetics Humans Model development Molecular Biology Biological sciences 030304 developmental biology 0303 health sciences Human Genome Computational Biology Cell Biology Shared resource Visualization Good Health and Well Being 030220 oncology & carcinogenesis Metabolome Biochemistry and Cell Biology Software Biotechnology |
| Zdroj: | Robinson, J L, Kocabaş, P, Wang, H, Cholley, P E, Cook, D, Nilsson, A, Anton, M, Ferreira, R, Domenzain, I, Billa, V, Limeta, A, Hedin, A, Gustafsson, J, Kerkhoven, E J, Svensson, L T, Palsson, B O, Mardinoglu, A, Hansson, L, Uhlén, M & Nielsen, J 2020, ' An atlas of human metabolism ', Science Signaling, vol. 13, no. 624, eaaz1482 . https://doi.org/10.1126/scisignal.aaz1482 Science signaling, vol 13, iss 624 Sci Signal Science Signaling |
| ISSN: | 1937-9145 1945-0877 |
| Popis: | Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and provide a scaffold for the integrative analysis of omics data. Researchers have developed increasingly comprehensive human GEMs, but the disconnect among different model sources and versions impedes further progress. We therefore integrated and extensively curated the most recent human metabolic models to construct a consensus GEM, Human1. We demonstrated the versatility of Human1 through the generation and analysis of cell- and tissue-specific models using transcriptomic, proteomic, and kinetic data. We also present an accompanying web portal, Metabolic Atlas (https://www.metabolicatlas.org/), which facilitates further exploration and visualization of Human1 content. Human1 was created using a version-controlled, open-source model development framework to enable community-driven curation and refinement. This framework allows Human1 to be an evolving shared resource for future studies of human health and disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|