AnnexinA7 promotes epithelial–mesenchymal transition by interacting with Sorcin and contributes to aggressiveness in hepatocellular carcinoma
Autor: | Jun Zhang, Li Hou, Xiao Yu, Huan Zhang, Qingqing Zhang, Fei Ling, Yunliang Sun, Jinyi Meng, He Huang, Jaceline Gislaine Pires Sanches, Bo Wang |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Cancer Research Carcinoma Hepatocellular Epithelial-Mesenchymal Transition Immunology Mice Nude Biology Transfection Article Metastasis Mice Cellular and Molecular Neuroscience Medical research Cell Movement In vivo Cell Line Tumor Genetics research medicine Animals Humans Annexin A7 Neoplasm Invasiveness Epithelial–mesenchymal transition neoplasms Cell Proliferation Mice Inbred BALB C Gene knockdown Transition (genetics) QH573-671 Mechanism (biology) Calcium-Binding Proteins Liver Neoplasms Cell Biology medicine.disease Xenograft Model Antitumor Assays In vitro digestive system diseases Tumor Burden Hepatocellular carcinoma Cancer research Female Cytology Signal Transduction |
Zdroj: | Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021) Cell Death & Disease |
ISSN: | 2041-4889 |
Popis: | Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and metastasis is the major cause of the high mortality of HCC. In this study, we identified that AnnexinA7 (ANXA7) and Sorcin (SRI) are overexpressed and interacting proteins in HCC tissues and cells. In vitro functional investigations revealed that the interaction between ANXA7 and SRI regulated epithelial–mesenchymal transition (EMT), and then affected migration, invasion, and proliferation in HCC cells. Furthermore overexpression/knockdown of ANXA7 was remarkably effective in promoting/inhibiting tumorigenicity and EMT in vivo. Altogether, our study unveiled a mechanism that ANXA7 promotes EMT by interacting with SRI and further contributes to the aggressiveness in HCC, which provides a novel potential therapeutic target for preventing recurrence and metastasis in HCC. |
Databáze: | OpenAIRE |
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