Hydroethanolic Extract from Bridelia atroviridis Müll. Arg. Bark Improves Haematological and Biochemical Parameters in Nicotinamide-/Streptozotocin-Induced Diabetic Rats
| Autor: | Bruno Ndjakou Lenta, Clemence Donfack Gouni, Rodrigue Fifen, Jean Philippe Djientcheu, Raceline Kamkumo Gounoue, Desire Paul Djomeni Dzeufiet, Antoine Kavaye Kandeda, Théophile Dimo, Silvère Ngouela, Norbert Sewald, Florence Tsofack Ngueguim, Clarice Noussi Djouwoug |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
Article Subject medicine.medical_treatment Pharmacology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound Other systems of medicine 0302 clinical medicine Insulin resistance Leukocytopenia Diabetes mellitus medicine 030304 developmental biology 0303 health sciences business.industry Insulin Glutathione medicine.disease Streptozotocin Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis business Oxidative stress RZ201-999 medicine.drug |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020) |
| ISSN: | 1741-427X |
| DOI: | 10.1155/2020/3160834 |
| Popis: | Bridelia atroviridis Müll. Arg. (B. atroviridis) is a plant used in Cameroonian traditional medicine to manage diabetes. The effects of hydroethanolic barks extract from B. atroviridis were evaluated on diabetes disorders including hematology, inflammatory, and oxidative stress parameters. The in vitro antioxidant capacity of the hydroethanolic bark extract (70 : 30) was evaluated. Nicotinamide-/streptozotocin-induced diabetic rats were daily treated with the B. atroviridis extract for fifteen days. Glycemia were evaluated every 5 days, insulin sensibility test was performed, and haematological, inflammatory, and oxidative stress parameters were analysed. Histomorphometry of the pancreas was realized. The extract was able to scavenge free radicals in vitro and decrease significantly the blood glucose levels. The treatment resulted in a significant alleviation of insulin resistance, anemia, leukocytopenia, and thrombocytopenia observed in untreated diabetic rats. The extract significantly decreased proinflammatory cytokines TNF-α, IL-1β, and IL-10. The rate of reduced glutathione was increased in the pancreas, whereas the catalase activity and nitrite concentration were decreased. Diabetic control showed a reduced size of Langerhans islet, whereas the size of islets was large in treated groups. The hydroethanolic extract of B. atroviridis was able to improve glycemia and alleviate haematological and inflammatory parameters disorders observed in diabetic conditions, probably due to its antidiabetic, anti-inflammatory, and antioxidant capacities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text