Fabrication and characterization of dextran/nanocrystalline β-tricalcium phosphate nanocomposite hydrogel scaffolds
| Autor: | Farahnaz Fahimipour, Erfan Dashtimoghadam, Hamed Salimi-Kenari, Rahil Ghaffari, Hassan Adeli, Sayed Mahmood Rabiee |
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| Rok vydání: | 2020 |
| Předmět: |
Calcium Phosphates
Materials science Biocompatibility Nanogels Biocompatible Materials Chemistry Techniques Synthetic 02 engineering and technology Bone tissue Biochemistry Nanocomposites 03 medical and health sciences chemistry.chemical_compound Structural Biology Materials Testing Spectroscopy Fourier Transform Infrared medicine Bone regeneration Molecular Biology Mechanical Phenomena 030304 developmental biology 0303 health sciences Nanocomposite Molecular Structure Tissue Scaffolds Swelling capacity technology industry and agriculture Dextrans General Medicine 021001 nanoscience & nanotechnology Dextran medicine.anatomical_structure chemistry Chemical engineering Thermogravimetry Self-healing hydrogels Swelling medicine.symptom 0210 nano-technology Porosity |
| Zdroj: | International Journal of Biological Macromolecules. 148:434-448 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2020.01.112 |
| Popis: | Design of bioactive three-dimensional scaffolds to support bone tissue repair and regeneration become a key area of research in tissue engineering. Herein, porous hybrid hydrogels composed of dextran incorporated with nanocrystalline β-tricalcium phosphate (β-TCP) particles were tailor made as scaffolds for bone tissue engineering. β-TCP was successfully introduced within the dextran networks crosslinked through intermolecular ionic interactions and hydrogen bonding confirmed by FTIR spectroscopy. The effect of β-TCP content on equilibrium water uptake and swelling kinetics of composite hydrogels was investigated. It was found that the homogeneous distribution of β-TCP nanoparticles through the hydrogel matrix contributes to higher porosity and swelling capacity. In depth swelling measurements revealed that while in the early stage of swelling, water diffusion follows the Fick's law, for longer time swelling behavior of hydrogels undergo the second order kinetics. XRD measurements represented the formation of apatite layer on the surface of nanocomposite hydrogels after immersion in the SBF solution, which implies their bioactivity. Cell culture assays confirmed biocompatibility of the developed hybrid hydrogels in vitro. The obtained results converge to offer dextran/β-TCP nanocomposite hydrogels as promising scaffolds for bone regeneration applications. |
| Databáze: | OpenAIRE |
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