Development of humanized mouse with patient‐derived xenografts for cancer immunotherapy studies: A comprehensive review

Autor: Ketao Jin, Wen-Lin Du, Chun-Sen Mao, Yuyao Liu, Xiao-Zhou Mou, Jin-Lin Du, Huan-Rong Lan
Rok vydání: 2021
Předmět:
Graft Rejection
0301 basic medicine
Cancer Research
medicine.medical_treatment
Transplantation
Heterologous
Graft vs Host Disease
Context (language use)
Review Article
Mice
SCID
Computational biology
Immunotherapy
Adoptive
Human equivalent
immunology
Translational Research
Biomedical
Mice
03 medical and health sciences
0302 clinical medicine
Immune system
Drug Development
Cancer immunotherapy
Neoplasms
human specificity
medicine
Animals
Humans
Precision Medicine
Review Articles
patient‐derived xenografts
business.industry
Antibodies
Monoclonal
General Medicine
Immunotherapy
Xenograft Model Antitumor Assays
Killer Cells
Natural
Disease Models
Animal
humanized mice
030104 developmental biology
Oncology
Drug development
030220 oncology & carcinogenesis
Humanized mouse
Cytokines
Intercellular Signaling Peptides and Proteins
Personalized medicine
Genetic Engineering
business
Zdroj: Cancer Science
ISSN: 1349-7006
1347-9032
DOI: 10.1111/cas.14934
Popis: Immunotherapy has revolutionized cancer treatment, however, not all tumor types and patients are completely responsive to this approach. Establishing predictive pre‐clinical models would allow for more accurate and practical immunotherapeutic drug development. Mouse models are extensively used as in vivo system for biomedical research. However, due to the significant differences between rodents and human, it is impossible to translate most of the findings from mouse models to human. Pharmacological development and advancing personalized medicine using patient‐derived xenografts relies on producing mouse models in which murine cells and genes are substituted with their human equivalent. Humanized mice (HM) provide a suitable platform to evaluate xenograft growth in the context of a human immune system. In this review, we discussed recent advances in the generation and application of HM models. We also reviewed new insights into the basic mechanisms, pre‐clinical evaluation of onco‐immunotherapies, current limitations in the application of these models as well as available improvement strategies. Finally, we pointed out some issues for future studies.
Establishing predictive pre‐clinical models leads toward more accurate and practical immunotherapeutic development. Humanized mice (HM) provide a suitable platform to discern human‐specific disease pathogenesis and evaluate an array of novel therapeutics. This review discusses recent progresses in the production and deployment of HM in the study of cancer immunotherapy.
Databáze: OpenAIRE
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