Nondegradable hydrogels for the treatment of focal cartilage defects
| Autor: | Peter A. Torzilli, S. B. Doty, E. Myers, Russell F. Warren, Anthony M. Lowman, S. Thornton, Suzanne A. Maher, Jonathan Thomas, Timothy M. Wright |
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| Rok vydání: | 2007 |
| Předmět: |
Materials science
Cartilage technology industry and agriculture Metals and Alloys Biomedical Engineering Implantation Site Modulus Soft tissue Hydrogels Prostheses and Implants Elasticity Biomaterials medicine.anatomical_structure Self-healing hydrogels Ceramics and Composites medicine Animals Joints Rabbits Implant Deformation (engineering) Cartilage Diseases Biomedical engineering Fixation (histology) |
| Zdroj: | Journal of Biomedical Materials Research Part A. :145-155 |
| ISSN: | 1552-4965 1549-3296 |
| Popis: | Nondegradable materials have long been suggested for the treatment of articular cartilage defects; however, the mechanics of the implant/tissue system necessary to ensure long-term function are unknown. The objective of this study was to explore the performance of nondegradable hydrogel implants in cartilage defects. Our hypothesis was that the structural integrity of the implant and surrounding tissue would be influenced by the compressive modulus of the material used, and that superior results would be obtained with the implantation of a more compliant material. Poly(vinyl alcohol)-poly(vinyl pyrrolidone) hydrogel implants of two different moduli were implanted into osteochondral defects in a rabbit model. Six-month postoperative histological and mechanical data were used to assess the wear and fixation of the implants. The compliant implants remained well fixed and a thin layer of soft tissue grew over the surface of the implants. However, gross deformation of the compliant implants occurred and debris was evident in surrounding bone. The stiffer implants were dislocated from their implantation site, but with no accompanying evidence of debris or implant deformation. Our hypothesis that superior results would be obtained with implantation of a more compliant material was rejected; a compromise between the wear and fixation properties dependent on modulus was found. |
| Databáze: | OpenAIRE |
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