The Environmental Exposures and Inner- and Intercity Traffic Flows of the Metro System May Contribute to the Skin Microbiome and Resistome
| Autor: | Kang Kang, Chinmoy Sarkar, Gianni Panagiotou, Chris Webster, Tingting Zheng, Caroline Dingle, S Denizen, Cheong Wai Martin Wong, Anand Archna, Jun Li, Yueqiong Ni, David M. Baker, Yoshitaro Heshiki, Lejla Imamovic, Sarika Kumari, Marie Danielle Kobler, Morten Otto Alexander Sommer, Jane Ching Yan Wong |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Biology Antibiotic resistance gene General Biochemistry Genetics and Molecular Biology law.invention 03 medical and health sciences SDG 3 - Good Health and Well-being law ARG transmission Recurrence Environmental health Drug Resistance Bacterial Humans Microbiome Microbial signature Railroads Skin Vancomycin resistance Microbiota ARG Environmental Exposure Resistome 030104 developmental biology Transmission (mechanics) Metagenomics Hong Kong Metagenome Sampling time Metro system Antibiotic resistance genes |
| Zdroj: | Kang, K, Ni, Y, Li, J, Imamovic, L, Sarkar, C, Kobler, M D, Heshiki, Y, Zheng, T, Kumari, S, Wong, J C Y, Archna, A, Wong, C W M, Dingle, C, Denizen, S, Baker, D M, Sommer, M O A, Webster, C J & Panagiotou, G 2018, ' The Environmental Exposures and Inner-and Intercity Traffic Flows of the Metro System May Contribute to the Skin Microbiome and Resistome ', Cell Reports, vol. 24, no. 5, pp. 1190-1202 . https://doi.org/10.1016/j.celrep.2018.06.109 |
| ISSN: | 2211-1247 |
| Popis: | Summary The skin functions as the primary interface between the human body and the external environment. To understand how the microbiome varies within urban mass transit and influences the skin microbiota, we profiled the human palm microbiome after contact with handrails within the Hong Kong Mass Transit Railway (MTR) system. Intraday sampling time was identified as the primary determinant of the variation and recurrence of the community composition, whereas human-associated species and clinically important antibiotic resistance genes (ARGs) were captured as p.m. signatures. Line-specific signatures were notably correlated with line-specific environmental exposures and city characteristics. The sole cross-border line appeared as an outlier in most analyses and showed high relative abundance and a significant intraday increment of clinically important ARGs (24.1%), suggesting potential cross-border ARG transmission, especially for tetracycline and vancomycin resistance. Our study provides an important reference for future public health strategies to mitigate intracity and cross-border pathogen and ARG transmission. |
| Databáze: | OpenAIRE |
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