T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosa
| Autor: | Jacqueline Mahlo, Ingo Bechmann, Daniel Richter, Erik Kwidzinski, Jana Goldmann, Christine Brandt |
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| Rok vydání: | 2006 |
| Předmět: |
CD4-Positive T-Lymphocytes
Pathology medicine.medical_specialty Meningeal lymphatic vessels Green Fluorescent Proteins Immunology Central nervous system Mice Transgenic Mucous membrane of nose Immune tolerance Lesion Mice Antigen Cell Movement medicine Animals Immunology and Allergy business.industry Brain Cell Biology Anatomy Entorhinal cortex Mice Inbred C57BL Disease Models Animal Ethmoid Bone Nasal Mucosa medicine.anatomical_structure Cervical lymph nodes Lymph Nodes medicine.symptom business Neck |
| Zdroj: | Journal of Leukocyte Biology. 80:797-801 |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1189/jlb.0306176 |
| Popis: | Although drainage pathways of soluble antigens from brain to cervical lymph nodes have been well established, there is no direct evidence for similar routes of leukocytes leaving the central nervous system. We developed a protocol allowing the cross-sectioning of an entire head-neck preparation while preserving the signal of the GFP. We monitored how GFP-expressing CD4 T lymphocytes injected into the entorhinal cortex after lesion or the lateral ventricle of unlesioned C57/bl6 mice reach cervical lymph nodes. Irrespective of the injection site, we demonstrate their passage through the cribroid plate, appearance in the nasal mucosa, and specific accumulation in one of the cervical lymph nodes. |
| Databáze: | OpenAIRE |
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