In vitro assays used in the evaluation of the quality of stored platelets: Correlation with in vivo assays
| Autor: | Stein Holme |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Pathology medicine.medical_specialty Blood Volume Platelet Function Tests Cell Survival Platelet Count In vitro toxicology Blood volume Platelet Transfusion Hematology Platelet storage Biology In vitro Correlation Andrology Blood Preservation Predictive Value of Tests In vivo Isotope Labeling medicine Humans Female Platelet Algorithms |
| Zdroj: | Transfusion and Apheresis Science. 39:161-165 |
| ISSN: | 1473-0502 |
| DOI: | 10.1016/j.transci.2008.06.007 |
| Popis: | There have been reports on platelet storage studies that have demonstrated little or no correlation of in vitro parameters with in vivo parameters of viability such as CCI, and % recovery and survival by radio labeling. However, this does not mean that the in vitro parameters necessarily are poor predictor of in vivo viability, but may be related to the fact that in the vivo parameters, as absolute values, do not precisely reflect the viability of the platelets due to uncertainty in the splenic uptake and inaccuracy of the estimated blood volume of the recipient. A more informative way to examine the predictability of the in vitro parameters is to examine whether processing and storage conditions associated with loss or improvement in vivo viability are also associated with corresponding changes to the in vitro parameters and vice versa. |
| Databáze: | OpenAIRE |
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