Measuring glucose at the site of insulin delivery with a redox-mediated sensor
| Autor: | Peter G. Jacobs, Sheila Benware, W. Kenneth Ward, Deborah Branigan, Nichole S. Tyler, Robert S. Cargill, Scott M. Vanderwerf, Katrina Ramsey, Clara Mosquera-Lopez, Jessica R. Castle, Thomas Seidl, Kristin Morris |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
medicine.medical_treatment Biomedical Engineering Biophysics Insulin delivery Insulin analog 02 engineering and technology Biosensing Techniques 01 natural sciences Article Insulin Infusion Systems Electrochemistry medicine Humans Hypoglycemic Agents Insulin Type 1 diabetes Artifact (error) Chemistry Blood Glucose Self-Monitoring 010401 analytical chemistry Phosphate buffered saline General Medicine 021001 nanoscience & nanotechnology medicine.disease Cannula 0104 chemical sciences medicine.anatomical_structure Diabetes Mellitus Type 1 Glucose 0210 nano-technology Oxidation-Reduction Biotechnology Biomedical engineering Subcutaneous tissue |
| Zdroj: | Biosens Bioelectron |
| ISSN: | 1873-4235 |
| Popis: | Automated insulin delivery systems for people with type 1 diabetes rely on an accurate subcutaneous glucose sensor and an infusion cannula that delivers insulin in response to measured glucose. Integrating the sensor with the infusion cannula would provide substantial benefit by reducing the number of devices inserted into subcutaneous tissue. We describe the sensor chemistry and a calibration algorithm to minimize impact of insulin delivery artifacts in a new glucose sensing cannula. Seven people with type 1 diabetes undergoing automated insulin delivery used two sensing cannulae whereby one delivered a rapidly-acting insulin analog and the other delivered a control phosphate buffered saline (PBS) solution with no insulin. While there was a small artifact in both conditions that increased for larger volumes, there was no difference between the artifacts in the sensing cannula delivering insulin compared with the sensing cannula delivering PBS as determined by integrating the area-under-the-curve of the sensor values following delivery of larger amounts of fluid (P=0.7). The time for the sensor to recover from the artifact was found to be longer for larger fluid amounts compared with smaller fluid amounts (10.3 ± 8.5 minutes vs. 41.2 ± 78.3 seconds, P |
| Databáze: | OpenAIRE |
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