Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions
| Autor: | Mujib Ullah, Gustavo Yannarelli, Asma Akbar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
Treatment outcome Early detection Bioinformatics lcsh:RC254-282 DETECTION 03 medical and health sciences 0302 clinical medicine Text mining Neoplasms RNA EDITING Medicine Humans RNA Neoplasm Precision Medicine purl.org/becyt/ford/3.4 [https] Survival rate Letter to the Editor Early Detection of Cancer 030304 developmental biology 0303 health sciences business.industry Cancer medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens CANCER Neoplasm Proteins Oncology RNA editing Drug Resistance Neoplasm 030220 oncology & carcinogenesis purl.org/becyt/ford/3 [https] RNA Editing business |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Technology in Cancer Research & Treatment Technology in Cancer Research & Treatment, Vol 19 (2020) |
| Popis: | Early detection of cancer has great clinical importance and potentially improves cure, survival rate and treatment outcome. RNA editing technology can be used as targeted and precise molecular scissors to cut and replace disease-causing genes with healthy ones. This is a post transcriptional modification that can lead to the recoding of proteins. RNA editing technology is in its infancy, but it can be used for early diagnoses and effective treatment of cancer. The full potential of precision medicine will be achieved by using the knowledge of RNA reversible-recoding to edit the protein. RNA editing technology could be used to expose chemo resistant cancer cells, dormant cancer stem cells and other malignant tumors. RNA editing generates RNA and protein diversity to accelerate and enhance the screening window for early detection of cancer. We propose that the RNA editing sites could be used as a novel tool for early detection of cancer. Fil: Mujib, Ullah. University of Stanford; Estados Unidos Fil: Asma, Akbar. University of Stanford; Estados Unidos Fil: Yannarelli, Gustavo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina |
| Databáze: | OpenAIRE |
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