Presynaptic Inhibitory Effects of Acetylcholine in the Hippocampus: A 40-Year Evolution of a Serendipitous Finding
| Autor: | Rita J. Valentino, Raymond Dingledine |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Hippocampal slice Hippocampus Hippocampal formation Inhibitory postsynaptic potential History 21st Century 03 medical and health sciences 0302 clinical medicine Organ Culture Techniques medicine Humans Recall General Neuroscience Neurophysiology History 20th Century Progressions Acetylcholine 030104 developmental biology Neurology Cholinergic Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | J Neurosci |
| ISSN: | 1529-2401 |
| Popis: | Cholinergic regulation of hippocampal circuit activity has been an active area of neurophysiological research for decades. The prominent cholinergic innervation of intrinsic hippocampal circuitry, potent effects of cholinomimetic drugs, and behavioral responses to cholinergic modulation of hippocampal circuitry have driven investigators to discover diverse cellular actions of acetylcholine in distinct sites within hippocampal circuitry. Further research has illuminated how these actions organize circuit activity to optimize encoding of new information, promote consolidation, and coordinate this with recall of prior memories. The development of the hippocampal slice preparation was a major advance that accelerated knowledge of how hippocampal circuits functioned and how acetylcholine modulated these circuits. Using this preparation in the early 1980s, we made a serendipitous finding of a novel presynaptic inhibitory effect of acetylcholine on Schaffer collaterals, the projections from CA3 pyramidal neurons to dendrites of CA1 pyramidal cells. We characterized this effect at cellular and pharmacological levels, published the findings in the first volume of theJournal of Neuroscience, and proceeded to pursue other scientific directions. We were surprised and thrilled to see that, nearly 40 years later, the paper is still being cited and downloaded because the data became an integral piece of the foundation of the science of cholinergic regulation of hippocampal function in learning and memory. This Progressions article is a story of how single laboratory findings evolve through time to be confirmed, challenged, and reinterpreted by other laboratories to eventually become part of the basis of fundamental concepts related to important brain functions. |
| Databáze: | OpenAIRE |
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