Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner

Autor: Simon Stark, Phil Salmon, Todd A. Sasser, Stuart S. Berr, Willy Gsell, Krzysztof Mińczuk, Ali A Attarwala, C. Correcher, Sonica Van Wyk, Sven Junge, Uwe Himmelreich, Kjell Laperre, Cesar Molinos, Bijoy Kundu, Jie Li, James C. Massey, Ali N. Bahadur, John O. Prior, David Viertl, Michael Heidenreich
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Frontiers in Medicine, Vol 6 (2019)
Frontiers in medicine, vol. 6, pp. 88
Frontiers in Medicine
Popis: Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing radiation. CT doses in pre-clinical in vivo imaging typically range from 50 to 1,000 mGy and biological effects in mice at this dose range have been previously described. [18F]FDG body doses in mice have been estimated to be in the range of 100 mGy for [18F]FDG. Yearly, the average whole body doses due to handling of activity by PET technologists are reported to be 3-8 mSv. A preclinical PET/CT system is presented with design features which make it suitable for small animal low-dose imaging. The CT subsystem uses a X-source power that is optimized for small animal imaging. The system design incorporates a spatial beam shaper coupled with a highly sensitive flat-panel detector and very fast acquisition (
Databáze: OpenAIRE