Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner
| Autor: | Simon Stark, Phil Salmon, Todd A. Sasser, Stuart S. Berr, Willy Gsell, Krzysztof Mińczuk, Ali A Attarwala, C. Correcher, Sonica Van Wyk, Sven Junge, Uwe Himmelreich, Kjell Laperre, Cesar Molinos, Bijoy Kundu, Jie Li, James C. Massey, Ali N. Bahadur, John O. Prior, David Viertl, Michael Heidenreich |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Scanner
Materials science Image quality TECHNOLOGISTS Imaging phantom 030218 nuclear medicine & medical imaging Ionizing radiation 03 medical and health sciences 0302 clinical medicine Silicon photomultiplier Medicine General & Internal MICRO-COMPUTED TOMOGRAPHY General & Internal Medicine Methods preclinical X-RAY TUBE DAMAGE PET-CT lcsh:R5-920 Dynamic Scan Science & Technology [F-18]FDG business.industry imaging General Medicine DOSIMETRY BONE ARCHITECTURE 3. Good health IRRADIATION MODEL PET total-body low dose 030220 oncology & carcinogenesis oncology Medicine CT [18F]FDG Nuclear medicine business lcsh:Medicine (General) Life Sciences & Biomedicine Preclinical imaging |
| Zdroj: | Frontiers in Medicine, Vol 6 (2019) Frontiers in medicine, vol. 6, pp. 88 Frontiers in Medicine |
| Popis: | Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing radiation. CT doses in pre-clinical in vivo imaging typically range from 50 to 1,000 mGy and biological effects in mice at this dose range have been previously described. [18F]FDG body doses in mice have been estimated to be in the range of 100 mGy for [18F]FDG. Yearly, the average whole body doses due to handling of activity by PET technologists are reported to be 3-8 mSv. A preclinical PET/CT system is presented with design features which make it suitable for small animal low-dose imaging. The CT subsystem uses a X-source power that is optimized for small animal imaging. The system design incorporates a spatial beam shaper coupled with a highly sensitive flat-panel detector and very fast acquisition ( |
| Databáze: | OpenAIRE |
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