Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases

Autor: Aurelian Radu, Nicolae Ghinea, Philippe Camparo, Gaëlle Fromont, Martine Antoine, François Planeix, Julie Gonin, Christophe Pichon, Virginie Desestret, Michel Huerre, Ahsan Siraj, Marc Sanson
Přispěvatelé: BMC, Ed., Département de Recherche Translationnelle, Institut Curie [Paris], Laboratoire de Neuropathologie Raymond Escourolle [CHU Pitié-Salpétriêre], Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'Anatomie et cytologie pathologiques [CHU Tenon], CHU Tenon [AP-HP], Service d'Anatomie et de Cytologie Pathologiques [Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Histotechnologie et Pathologie, Institut Pasteur [Paris] (IP), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UPMC - Département de neurologie 2 - Mazarin, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Centre de pathologie Amiens, Centre de pathologie Amiens - Picardie, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Département de recherche translationnelle, Institut Curie, Laboratoire de Neuropathologie Raymond Escourolle, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Service d'anatomie pathologique [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Tenon [APHP], Institut Pasteur [Paris], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Pierre et Marie Curie - Paris 6 (UPMC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Rok vydání: 2012
Předmět:
Male
Leiomyosarcoma
Cancer Research
Pathology
Lung Neoplasms
Endothelial cells
Estrogen receptor
Metastasis
Prostate cancer
0302 clinical medicine
Breast cancer
Neoplasms
Medicine
Neoplasm Metastasis
Lymph node
0303 health sciences
Tumor blood vessels
Kidney cancer
Middle Aged
Kidney Neoplasms
Colon cancer
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Lymphatic Metastasis
Colonic Neoplasms
Uterine Neoplasms
Receptors
FSH
Female
Lung cancer
Research Article
Adult
medicine.medical_specialty
endocrine system
Endothelium
[SDV.CAN]Life Sciences [q-bio]/Cancer
Breast Neoplasms
03 medical and health sciences
Young Adult
[SDV.CAN] Life Sciences [q-bio]/Cancer
Genetics
Humans
030304 developmental biology
Aged
Follicle-stimulating hormone receptor
business.industry
Cancer
Prostatic Neoplasms
medicine.disease
Microvessels
Endothelium
Vascular
business
Zdroj: BMC Cancer
BMC Cancer, 2013, 13 (1), pp.246. ⟨10.1186/1471-2407-13-246⟩
BMC Cancer, BioMed Central, 2013, 13 (1), pp.246. ⟨10.1186/1471-2407-13-246⟩
ISSN: 1471-2407
Popis: Background The Follicle Stimulating Hormone receptor (FSHR) is expressed by the vascular endothelium in a wide range of human tumors. It was not determined however if FSHR is present in metastases which are responsible for the terminal illness. Methods We used immunohistochemistry based on a highly FSHR-specific monoclonal antibody to detect FSHR in cancer metastases from 6 major tumor types (lung, breast, prostate, colon, kidney, and leiomyosarcoma ) to 6 frequent locations (bone, liver, lymph node, brain, lung, and pleura) of 209 patients. Results In 166 patients examined (79%), FSHR was expressed by blood vessels associated with metastatic tissue. FSHR-positive vessels were present in the interior of the tumors and some few millimeters outside, in the normally appearing tissue. In the interior of the metastases, the density of the FSHR-positive vessels was constant up to 7 mm, the maximum depth available in the analyzed sections. No significant differences were noticed between the density of FSHR-positive vessels inside vs. outside tumors for metastases from lung, breast, colon, and kidney cancers. In contrast, for prostate cancer metastases, the density of FSHR-positive vessels was about 3-fold higher at the exterior of the tumor compared to the interior. Among brain metastases, the density of FSHR-positive vessels was highest in lung and kidney cancer, and lowest in prostate and colon cancer. In metastases of breast cancer to the lung pleura, the percentage of blood vessels expressing FSHR was positively correlated with the progesterone receptor level, but not with either HER-2 or estrogen receptors. In normal tissues corresponding to the host organs for the analyzed metastases, obtained from patients not known to have cancer, FSHR staining was absent, with the exception of approx. 1% of the vessels in non tumoral temporal lobe epilepsy samples. Conclusion FSHR is expressed by the endothelium of blood vessels in the majority of metastatic tumors.
Databáze: OpenAIRE
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