Copper-Catalyzed Formal Dehydrogenative Coupling of Carbonyls with Polyfluoroarenes Leading to β-C-H Arylation

Autor: Sukbok Chang, Dong-Wook Kim, Weilong Xie
Rok vydání: 2020
Předmět:
Zdroj: Journal of the American Chemical Society. 142(49)
ISSN: 1520-5126
Popis: We herein communicate a formal dehydrogenative coupling of carbonyls with polyfluoroarenes enabled by Cu catalysis. Silyl enol ethers initially prepared from carbonyls are postulated to undergo the copper-mediated oxidative dehydrogenative coupling with polyfluoroarenes via a radical pathway. Including cyclic and linear ketones, aldehydes, and esters, a broad range of β-aryl carbonyl products were efficiently obtained in high regio- and stereoselectivity with excellent functional group tolerance.
Databáze: OpenAIRE