Liposomes composed of partially hydrogenated egg phosphatidylcholines: fatty acid composition, thermal phase behavior and oxidative stability
Autor: | Carmen Vigo-Pelfrey, Francis J. Martin, Johanna Lang |
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Rok vydání: | 1990 |
Předmět: |
Chromatography
Gas Hot Temperature Chemical Phenomena Eggs Biochemistry chemistry.chemical_compound Drug Stability Phosphatidylcholine Organic chemistry Molecular Biology chemistry.chemical_classification Liposome Chemistry Physical Chemistry Fatty Acids Organic Chemistry Fatty acid Stereoisomerism Cell Biology Cis trans isomerization Oleic acid Docosahexaenoic acid Liposomes Phosphatidylcholines Arachidonic acid Stearic acid Oxidation-Reduction Nuclear chemistry |
Zdroj: | Chemistry and Physics of Lipids. 53:91-101 |
ISSN: | 0009-3084 |
DOI: | 10.1016/0009-3084(90)90137-g |
Popis: | Partially hydrogenated egg phosphatidylcholines (PHEPC) represent a new class of raw materials for liposome-based drug products. PHEPC were manufactured from native egge phosphatidylcholine (EPC) to iodine values (IV) 40, 30, 20, 10, and 1. Hydrogenation resulted in a complete loss of arachidonic acid (20:4) and docosahexaenoic acid (22:6) in IV 40 EPC and a progressive conversion of linoleic (18:2) and oleic acid (18:1) to stearic acid (18:0) at higher degrees of hydrogenation (IV 30, 20, 10, 1). Hydrogenation lead to formation of trans -fatty acid isomers maximally 18.5 mol% in IV 20 EPC. Liposomes made from IV 20, IV 10 and IV 1 EPC had marked phase transitions between 20 and 60°C. PHEPC showed increased resistance to oxidation as measured by oxygen uptake during 2,2′-azobis-(2-amidinopropane) hydrochloride (AAPH) initiated accelerated oxidation. Various applications of these new materials in the manufacture of liposomes and liposome based drug products are discussed. |
Databáze: | OpenAIRE |
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