Compositional variation in bacterial genes and proteins with potential expression level
| Autor: | Sabyasachi Das, Subhagata Ghosh, Chitra Dutta, Archana Pan |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Codon Adaptation Index
genetic structures Guanine Molecular Sequence Data education Biophysics Average size/complexity score Biology Amino acid usage Biochemistry Open Reading Frames chemistry.chemical_compound Bacterial Proteins Structural Biology Genetics Expressivity (genetics) Amino Acids Codon Molecular Biology Gene Alcoholicity Gene Expression Regulation Bacterial Cell Biology biology.organism_classification Codon adaptation index Synonymous codon usage Open reading frame chemistry Genes Bacterial Codon usage bias sense organs Cytosine Bacteria |
| Zdroj: | FEBS Letters. 579:5205-5210 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2005.08.042 |
| Popis: | Usage of guanine and cytosine at three codon sites in eubacterial genes vary distinctly with potential expressivity, as predicted by Codon Adaptation Index (CAI). In bacteria with moderate/high GC-content, G3 follows a biphasic relationship, while C3 increases with CAI. In AT-rich bacteria, correlation of CAI is negative with G3, but non-specific with C3. Correlations of CAI with residues encoded by G-starting codons are positive, while with those by C-starting codons are usually negative/random. Average Size/Complexity Score and aromaticity of gene-products decrease with CAI, confirming general validity of cost-minimization principle in free-living eubacteria. Alcoholicity of bacterial gene-products usually decreases with expressivity. |
| Databáze: | OpenAIRE |
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