Serum microRNA Biomarkers for Drug-Induced Liver Injury
| Autor: | P.J. Starkey Lewis, Jonathan G. Moggs, Philippe Couttet, Brian Kevin Park, James W. Dear, D.J. Antoine, M Merz, Olivier Grenet, Christopher E. Goldring |
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| Rok vydání: | 2012 |
| Předmět: |
Drug
Oncology medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions media_common.quotation_subject Context (language use) Pharmacology Mice Internal medicine microRNA medicine Animals Humans Pharmacology (medical) Serum microrna media_common Liver injury Acute liver injury business.industry medicine.disease ACETAMINOPHEN TOXICITY MicroRNAs Circulating MicroRNA Liver Chemical and Drug Induced Liver Injury business Biomarkers |
| Zdroj: | Clinical Pharmacology & Therapeutics. 92:291-293 |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1038/clpt.2012.101 |
| Popis: | New biomarkers of drug-induced liver injury (DILI) are required in the clinic and in preclinical pharmaceutical evaluation. Liver-enriched microRNAs are promising serum biomarkers of acetaminophen-induced acute liver injury in mice. The utility of circulating microRNAs as biomarkers of human acute DILI is discussed in the context of correlation with existing biomarkers of liver injury and patient outcomes in acetaminophen toxicity, mechanisms of cellular microRNA release, and their potential advantages over current clinical biomarkers of DILI. |
| Databáze: | OpenAIRE |
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