Metal complexes of benzodiazepines. Kinetic properties of bromazepam toward square planar dimethyl sulfoxide complexes of platinum(II) and palladium(II)
| Autor: | Domenico Minniti, Matteo Cusumano, Antonino Giannetto |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Substitution reaction
Bromazepam Reaction mechanism Bicyclic molecule Stereochemistry chemistry.chemical_element Associative substitution Medicinal chemistry Inorganic Chemistry Reaction rate constant chemistry Materials Chemistry medicine Physical and Theoretical Chemistry Platinum medicine.drug Palladium |
| Zdroj: | Inorganica Chimica Acta. 215:41-45 |
| ISSN: | 0020-1693 |
| DOI: | 10.1016/0020-1693(93)03654-s |
| Popis: | The kinetics of substitution reactions of Me 2 SO from the complexes [MX 2 (Me 2 SO) 2 ] (M=Pt, X=Cl, CH 3 , cis ; M=Pd, X=Cl, trans ) by the ligands bromazepam or bipy have been investigated in Me 2 SO and/or CH 2 Cl 2 at 25 °C. The results are interpreted in terms of an associative mechanism for cis -[PtCl 2 (Me 2 SO) 2 ] and a dissociative mechanism for cis -[PtMe 2 (Me 2 SO) 2 ]. The substitution reaction for the complex trans -[PdCl 2 (Me 2 SO) 2 ] proceeds without retention of stereochemistry; a consecutive displacement mechanism or a pseudo-rotation mechanism can be operative. The kinetic behaviour of bromazepam and bipy is very similar. |
| Databáze: | OpenAIRE |
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