Effect of SX-3228, a selective ligand for the BZ1 receptor, on sleep and waking during the light-dark cycle in the rat
Autor: | Daniel Monti, J.M. Monti, H. Jantos, F. Alvariño |
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Jazyk: | angličtina |
Rok vydání: | 1999 |
Předmět: |
Agonist
medicine.medical_specialty Physiology medicine.drug_class Period (gene) Immunology Biophysics Sleep REM Walking Biochemistry Hypnotic Internal medicine medicine SX-3228 Animals Hypnotics and Sedatives General Pharmacology Toxicology and Pharmaceutics Naphthyridines Rats Wistar sleep waking Receptor lcsh:QH301-705.5 Lighting Slow-wave sleep lcsh:R5-920 Chemistry General Neuroscience benzodiazepine1 receptor Cell Biology General Medicine Darkness Ligand (biochemistry) Sleep in non-human animals Rats light-dark cycle Endocrinology lcsh:Biology (General) REM sleep lcsh:Medicine (General) Sleep zolpidem medicine.drug |
Zdroj: | Brazilian Journal of Medical and Biological Research v.32 n.8 1999 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 32, Iss 8, Pp 1007-1014 (1999) Brazilian Journal of Medical and Biological Research, Volume: 32, Issue: 8, Pages: 1007-1014, Published: AUG 1999 |
Popis: | The effects of the benzodiazepine1 (BZ1) receptor agonist SX-3228 were studied in rats (N = 12) implanted for chronic sleep procedures. Administration of 0.5, 1.0 and 2.5 mg/kg SX-3228, sc, to rats 1 h after the beginning of the light phase of the light-dark cycle induced a significant reduction of rapid-eye-movement sleep (REMS) during the third recording hour. Moreover, slow wave sleep (SWS) was increased during the fourth recording hour after the two largest doses of the compound. Administration of 0.5, 1.0 and 2.5 mg/kg SX-3228 one hour after the beginning of the dark period of the light-dark cycle caused a significant and maintained (6-h recording period) reduction of waking (W), whereas SWS and light sleep (LS) were increased. REMS values tended to increase during the entire recording period; however, the increase was statistically significant only for the 1.0 mg/kg dose during the first recording hour. In addition, a significant and dose-related increase of power density in the delta and the theta regions was found during nonREM sleep (LS and SWS) in the dark period. Our results indicate that SX-3228 is a potent hypnotic when given to the rat during the dark period of the light-dark cycle. Moreover, the sleep induced by SX-3228 during the dark phase closely resembles the physiological sleep of the rat. |
Databáze: | OpenAIRE |
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