| Autor: |
John C. Roberts, Peter V. Pallai, Julius Rebek, Ahcene Boumendjel, Hu Essa H |
| Rok vydání: |
1996 |
| Předmět: |
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| Zdroj: |
The Journal of organic chemistry. 61(13) |
| ISSN: |
1520-6904 |
| Popis: |
We describe the asymmetric synthesis of non-peptidic compounds that feature rigid backbone conformations and present various side-chain functions. The key step in the synthesis of these compounds is the C-acylation of an appropriate ketone with a suitably protected aspartic acid derivative. The resulting dipeptide modules may be connected to form tetrapeptide mimics. Specifically is described the mimicry of a four-residue segment of CD4, the cellular receptor of HIV-1. The design was based on molecular modeling and the X-ray crystal structures of CD4 and intended to present the most important side chains and backbone elements of the Phe43-Lys46 segment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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