Conversion of Pregabalin to 4-Isobutylpyrrolidone-2
| Autor: | Drew A. Fowler, Wei G. Wycoff, Harshita Kumari, Charles L. Barnes, Carol A. Deakyne, John E. Adams, Amanda M. Drachnik, Collin M. Mayhan, Jerry L. Atwood |
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| Rok vydání: | 2017 |
| Předmět: |
Quantum chemical
Pregabalin Pharmaceutical Science 010402 general chemistry 01 natural sciences Cocrystal Pyrrolidinones 0104 chemical sciences Nitrobenzene 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry medicine Organic chemistry Nitrobenzenes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 106:3095-3102 |
| ISSN: | 0022-3549 |
| Popis: | Solid-state studies of C-butyl-resorcin[4]arene with pregabalin (Lyrica, Nervalin) in nitrobenzene yielded a cocrystal of C-butyl-resorcin[4]arene with 4-isobutylpyrrolidone-2. A combined experimental and quantum chemical investigation was implemented to further our understanding of the factors affecting the conversion process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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