Synthesis of 4-Halophosphaisocoumarins via Halocyclization of 2-(1-Alkynyl)phenylphosphonates

Autor:	Yi-Xiang Ding, Ai-Yun Peng
Rok vydání:	2006
Předmět:	Chemistry Organic Chemistry Drug Discovery Electrophile Organic chemistry Regioselectivity General Medicine Phenylphosphonic acid Biochemistry Medicinal chemistry
Zdroj:	ChemInform. 37
ISSN:	1522-2667 0931-7597
Popis:	A series of 4-halophosphaisocoumarins were prepared with high regioselectivity in good to excellent yields under mild conditions by the reaction of 2-(1-alkynyl)phenylphosphonic acid diesters with I 2 in CHCl 3 or ICl in CH 2 Cl 2 , or by the reaction of 2-(1-alkynyl)phenylphosphonic acid monoesters with NBS or NCS in DMF. Whether the alkynylphosphonates could cyclize or not was affected by the substituents, reaction solvents and electrophiles. A rationale for this reaction is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c086aeabde4118ee7bf0ec794bf741a https://doi.org/10.1002/chin.200606181 Zobrazit plný text záznamu Plný text