Synthesis of 4-Halophosphaisocoumarins via Halocyclization of 2-(1-Alkynyl)phenylphosphonates
Autor: | Yi-Xiang Ding, Ai-Yun Peng |
---|---|
Rok vydání: | 2006 |
Předmět: | |
Zdroj: | ChemInform. 37 |
ISSN: | 1522-2667 0931-7597 |
Popis: | A series of 4-halophosphaisocoumarins were prepared with high regioselectivity in good to excellent yields under mild conditions by the reaction of 2-(1-alkynyl)phenylphosphonic acid diesters with I 2 in CHCl 3 or ICl in CH 2 Cl 2 , or by the reaction of 2-(1-alkynyl)phenylphosphonic acid monoesters with NBS or NCS in DMF. Whether the alkynylphosphonates could cyclize or not was affected by the substituents, reaction solvents and electrophiles. A rationale for this reaction is discussed. |
Databáze: | OpenAIRE |
Externí odkaz: |