Cutting edge: thymic NK cells develop independently from T cell precursors
| Autor: | Laurent Boucontet, Milena Hasan, James P. Di Santo, Vera S. G. Ribeiro, Pablo Pereira, Sarah Lesjean-Pottier, Naoko Satoh-Takayama, Christian A. J. Vosshenrich, Anne Wilson |
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| Přispěvatelé: | Immunité Innée - Innate Immunity, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), PhD programme in Experimental Biology and Biomedicine, University of Coimbra [Portugal] (UC)-Center for Neurosciences and cell biology, Developmental Immunology Group, Ludwig Institute for Cancer Research Ltd., Développement des Lymphocytes, Vougny, Marie-Christine, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
[SDV.IMM] Life Sciences [q-bio]/Immunology
T cell Immunology Population Mice Transgenic Cell Separation Thymus Gland Biology Polymerase Chain Reaction Mice 03 medical and health sciences Interleukin 21 0302 clinical medicine medicine Animals Immunology and Allergy Cell Lineage IL-2 receptor Progenitor cell education Interleukin-7 receptor 030304 developmental biology Precursor Cells T-Lymphoid 0303 health sciences education.field_of_study Janus kinase 3 Cell Differentiation Flow Cytometry Hematopoietic Stem Cells Cell biology Killer Cells Natural Mice Inbred C57BL medicine.anatomical_structure Interleukin 12 [SDV.IMM]Life Sciences [q-bio]/Immunology 030215 immunology |
| Zdroj: | Journal of Immunology Journal of Immunology, 2010, 185 (9), pp.4993-7. ⟨10.4049/jimmunol.1002273⟩ Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (9), pp.4993-7. ⟨10.4049/jimmunol.1002273⟩ |
| ISSN: | 0022-1767 1550-6606 |
| DOI: | 10.4049/jimmunol.1002273⟩ |
| Popis: | Although NK cells in the mouse are thought to develop in the bone marrow, a small population of NK cells in the thymus has been shown to derive from a GATA3-dependent pathway. Characteristically, thymic NK cells express CD127 and few Ly49 molecules and lack CD11b. Because these NK cells develop in the thymus, the question of their relationship to the T cell lineage has been raised. Using several different mouse models, we find that unlike T cells, thymic NK cells are not the progeny of Rorc-expressing progenitors and do not express Rag2 or rearrange the TCRγ locus. We further demonstrate that thymic NK cells develop independently of the Notch signaling pathway, supporting the idea that thymic NK cells represent bona fide NK cells that can develop independently of all T cell precursors. |
| Databáze: | OpenAIRE |
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