Effects of Intravenous Verapamil on the Haemodynamic Response to Exercise in Patients with Angina Pectoris
| Autor: | David T. Kelly, Phillip J. Harris, S. Meares, N. M. B. Sadick, M. Hiroe, Gary S. Roubin, George J. Bautovich |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac output Cardiac Volume Angina Pectoris Angina Internal medicine Internal Medicine Humans Medicine Infusions Parenteral Pulmonary Wedge Pressure Cardiac Output Pulmonary wedge pressure End-systolic volume Ejection fraction business.industry Stroke Volume Stroke volume Middle Aged medicine.disease Oxygen medicine.anatomical_structure Verapamil Anesthesia Exercise Test cardiovascular system Vascular resistance Cardiology Vascular Resistance business medicine.drug |
| Zdroj: | Acta Medica Scandinavica. 215:91-98 |
| ISSN: | 0001-6101 |
| Popis: | The effects of intravenous Verapamil (V) on exercise haemodynamics and ventricular function were compared in 13 patients with stable effort angina. Intravascular pressures, thermodilution cardiac output and radionuclide ejection fraction were measured simultaneously at rest and during exercise. At rest Verapamil produced systemic vasodilation. During exercise at identical workloads compared to control, Verapamil increased cardiac index (CI) and decreased AVO2 difference. Pulmonary artery wedge pressure was lower. Ejection fraction was higher (control-55 +/- 11% vs V-64 +/- 11%) as the disproportionate increase in end systolic volume relative to the end diastolic volume was prevented. Verapamil is effective in exercise induced angina and alters haemodynamics primarily through its vasodilating properties associated with an increased CI. |
| Databáze: | OpenAIRE |
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