Frailty and Its Correlates in Adults With Late Life Depression
| Autor: | Benjamin Maas, Maleeha Naqvi, Sarah Chung, Kaleigh O'Boyle, Stephanie Gomez, Kay C. Igwe, Steven P. Roose, Adam Ciarleglio, Adam M. Brickman, Patrick J. Brown, Bret R. Rutherford |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Treatment response Frail Elderly Neuropsychological Tests Severity of Illness Index 03 medical and health sciences 0302 clinical medicine medicine Humans Depression (differential diagnoses) Aged Aged 80 and over Psychiatric Status Rating Scales 030214 geriatrics medicine.diagnostic_test Hand Strength business.industry Depression Neuropsychology Magnetic resonance imaging Late life depression Middle Aged Magnetic Resonance Imaging White Matter Gait speed Psychiatry and Mental health White matter hyperintensity Antidepressant Female Geriatrics and Gerontology business Clinical psychology |
| Zdroj: | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 28(2) |
| ISSN: | 1545-7214 |
| Popis: | To investigate the rates of frailty and frailty characteristics and examine the clinical and neuropsychological correlates of frailty in adults with late life depression (LLD).Data were used from the evaluation of 134 individuals over the age of 60 years (45 men, 89 women) with a depressive diagnosis who enrolled in studies for the treatment of their depression. Depression, neuropsychological functioning, white matter hyperintensity (WMH) burden via magnetic resonance imaging, and characteristics of frailty were assessed.Fried frailty burden (≥3 characteristics) was present in 25% of the sample, with this rate increasing to 45.5% when using clinically meaningful cut-scores for gait speed (1 m/s) and physical activity levels (1000 kcal/week). Moreover, 62% of the sample exhibited gait slowing (1 m/s) or weakness (grip strength), with 29% demonstrating both. Greater frailty burden was associated with greater Hamilton Depression Rating Scale severity in covariate adjusted linear regression models (tFindings from this study show that frailty, specifically physical frailty deficits in mobility and strength, is highly comorbid in adults with LLD, associated with greater depressive symptom severity, and does not appear to be associated with the vascular depression subtype of LLD. Future research should investigate the relationship between frailty and antidepressant treatment response as well as test whether there are age-related biological processes that result in the manifestation of the frail-depressed subtype of LLD. |
| Databáze: | OpenAIRE |
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