Treatment of hard-to-heal leg ulcers with hyaluronic acid, sodium alginate and negative pressure wound therapy
| Autor: | Hakan Uncu, Süleyman Utku Çelik, Can Yahya Boztug, Ömer Arda Çetinkaya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Nursing (miscellaneous) Alginates Lower Extremity Ulcer medicine.medical_treatment Poor quality 030207 dermatology & venereal diseases 03 medical and health sciences Wound care chemistry.chemical_compound 0302 clinical medicine Negative-pressure wound therapy Hyaluronic acid Medicine Humans 030212 general & internal medicine Hyaluronic Acid Sodium alginate Wound Healing business.industry Leg Ulcer Middle Aged Bandages Combined Modality Therapy Surgery Leg ulcer Treatment Outcome chemistry Fundamentals and skills Female business Negative-Pressure Wound Therapy |
| Zdroj: | Journal of wound care. 29(7) |
| ISSN: | 0969-0700 |
| Popis: | Objective: Hard-to-heal lower extremity ulcer is a common healthcare problem and can lead to a poor quality of life (QoL). Despite the advances in wound care, conventional therapies, such as necrotic tissue debridement, cleansing, treatment of infection and local treatment with dressing application are still considered the standard of care in patients with hard-to-heal leg ulcers. However, managing hard-to-heal ulcers that do not respond well to these methods has led to new treatment strategies. In this study, the effects of hyaluronic acid (HA) and sodium alginate (SA), combined with negative pressure wound therapy (NPWT), in patients with hard-to-heal leg ulcers are evaluated. Method: Patients with hard-to-heal lower extremity ulcers were treated with HA-SA combined with NPWT (HA-SA-NWPT, n=11), or conventional therapy (n=14), between June 2014 and September 2015. Demographics, comorbidities, time to complete healing and change in wound area were recorded and compared. Results: A total of 25 patients took part. Complete healing was achieved in 63.6% (n=7) of the patients in the HA-SA with NPWT group, compared with 14.3% (n=2) of the patients in the conventional therapy group (p=0.017). The mean decrease in wound size was significantly higher in the HA-SA-NPWT group than in the conventional therapy group (73.8% versus 34.8%, respectively, p=0.029). Despite a shorter healing period in the HA-SA-NPWT group than in the conventional group, no statistically significant difference was found between groups for time to complete healing (37 days versus 55 days, respectively). Conclusion: These results demonstrate that the combination of HA-SA-NPWT is a promising treatment for decreasing the healing time and increasing the success rate by their synergistic effect on wound healing in hard-to-heal lower extremity ulcers. However, further studies with a larger number of patients are needed to confirm the results. |
| Databáze: | OpenAIRE |
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