Association Between Alterations of the Choriocapillaris Microcirculation and Visual Function and Cone Photoreceptors in Patients With Diabetes
Autor: | Akihiro Ishibazawa, Tsuneaki Omae, Tomoko Ro-Mase, Akitoshi Yoshida, Akito Shimouchi, Satoshi Ishiko |
---|---|
Rok vydání: | 2020 |
Předmět: |
Adult
Male medicine.medical_specialty genetic structures Visual Acuity Type 2 diabetes optical coherence tomography angiography Retina 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Foveal Diabetes mellitus Ophthalmology visual function medicine Humans Fluorescein Angiography Aged 030304 developmental biology 0303 health sciences Diabetic Retinopathy medicine.diagnostic_test Choroid business.industry Microcirculation Retinal Vessels cone photoreceptors Retinal Diabetic retinopathy Middle Aged medicine.disease Fluorescein angiography eye diseases Diabetes Mellitus Type 2 chemistry choriocapillaris Retinal Cone Photoreceptor Cells 030221 ophthalmology & optometry Visual Field Tests Female sense organs Visual Fields business Microperimetry Tomography Optical Coherence Retinopathy |
Zdroj: | Investigative Ophthalmology & Visual Science |
ISSN: | 1552-5783 |
Popis: | Purpose The purpose of this study was to investigate the association between the choriocapillaris microcirculation and the visual function and cone photoreceptor structure in patients with diabetes. Methods Thirteen control subjects and 26 patients with type 2 diabetes were recruited. The patients with diabetes were divided into three groups based on the grade of diabetic retinopathy (DR). The retinal sensitivity (RS) was evaluated using microperimetry. Cone photoreceptor mosaics were imaged using an adaptive optics retinal camera, and the cone heterogeneity packing index (HPi) was calculated. Optical coherence tomography angiography (OCTA) images of the choriocapillaris were obtained using spectral-domain OCTA, and the area of flow deficit (FD) was evaluated. All parameters were evaluated in the foveal and parafoveal areas. Results The study included four patients with diabetes without retinopathy, 12 patients with nonproliferative diabetic retinopathy (NPDR), and 10 patients with proliferative diabetic retinopathy (PDR). The foveal and parafoveal FDs were correlated significantly (fovea, r = -0.58; P = 0.046 and r = -0.82; P = 0.003; parafovea, r = -0.59; P = 0.044 and r = -0.72; and P = 0.019, respectively) with the RS in patients with NPDR and PDR, but not in control and no diabetic retinopathy (NDR) groups. There were no differences in the foveal HPi among the groups. Conclusions Impaired choriocapillaris microcirculation is associated with impaired visual function but not cone photoreceptor integrity in eyes with DR. |
Databáze: | OpenAIRE |
Externí odkaz: |