Association Between Alterations of the Choriocapillaris Microcirculation and Visual Function and Cone Photoreceptors in Patients With Diabetes

Autor: Akihiro Ishibazawa, Tsuneaki Omae, Tomoko Ro-Mase, Akitoshi Yoshida, Akito Shimouchi, Satoshi Ishiko
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
genetic structures
Visual Acuity
Type 2 diabetes
optical coherence tomography angiography
Retina
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Foveal
Diabetes mellitus
Ophthalmology
visual function
medicine
Humans
Fluorescein Angiography
Aged
030304 developmental biology
0303 health sciences
Diabetic Retinopathy
medicine.diagnostic_test
Choroid
business.industry
Microcirculation
Retinal Vessels
cone photoreceptors
Retinal
Diabetic retinopathy
Middle Aged
medicine.disease
Fluorescein angiography
eye diseases
Diabetes Mellitus
Type 2
chemistry
choriocapillaris
Retinal Cone Photoreceptor Cells
030221 ophthalmology & optometry
Visual Field Tests
Female
sense organs
Visual Fields
business
Microperimetry
Tomography
Optical Coherence
Retinopathy
Zdroj: Investigative Ophthalmology & Visual Science
ISSN: 1552-5783
Popis: Purpose The purpose of this study was to investigate the association between the choriocapillaris microcirculation and the visual function and cone photoreceptor structure in patients with diabetes. Methods Thirteen control subjects and 26 patients with type 2 diabetes were recruited. The patients with diabetes were divided into three groups based on the grade of diabetic retinopathy (DR). The retinal sensitivity (RS) was evaluated using microperimetry. Cone photoreceptor mosaics were imaged using an adaptive optics retinal camera, and the cone heterogeneity packing index (HPi) was calculated. Optical coherence tomography angiography (OCTA) images of the choriocapillaris were obtained using spectral-domain OCTA, and the area of flow deficit (FD) was evaluated. All parameters were evaluated in the foveal and parafoveal areas. Results The study included four patients with diabetes without retinopathy, 12 patients with nonproliferative diabetic retinopathy (NPDR), and 10 patients with proliferative diabetic retinopathy (PDR). The foveal and parafoveal FDs were correlated significantly (fovea, r = -0.58; P = 0.046 and r = -0.82; P = 0.003; parafovea, r = -0.59; P = 0.044 and r = -0.72; and P = 0.019, respectively) with the RS in patients with NPDR and PDR, but not in control and no diabetic retinopathy (NDR) groups. There were no differences in the foveal HPi among the groups. Conclusions Impaired choriocapillaris microcirculation is associated with impaired visual function but not cone photoreceptor integrity in eyes with DR.
Databáze: OpenAIRE
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