Daily Ingestion of Eggplant Powder Improves Blood Pressure and Psychological State in Stressed Individuals: A Randomized Placebo-Controlled Study

Autor: Tomoyuki Fujita, Miho Suzuki, Shohei Yamaguchi, Kozo Nakamura, Jun Nishihira, Kazufumi Tsubaki, Mie Nishimura, Ryuto Takahashi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
eggplant
Placebo-controlled study
psychological state
lcsh:TX341-641
randomized controlled study
030204 cardiovascular system & hematology
Placebo
Gastroenterology
Placebo group
Article
law.invention
03 medical and health sciences
chemistry.chemical_compound
Eating
0404 agricultural biotechnology
0302 clinical medicine
Randomized controlled trial
Double-Blind Method
law
Internal medicine
medicine
Choline
Ingestion
Humans
Solanum melongena
Antihypertensive Agents
Nutrition and Dietetics
business.industry
food and beverages
blood pressure
04 agricultural and veterinary sciences
Middle Aged
040401 food science
acetylcholine
Blood pressure
chemistry
Dietary Supplements
Hypertension
Choline esters
Female
Powders
business
lcsh:Nutrition. Foods and food supply
Stress
Psychological
Food Science
Zdroj: Nutrients, Vol 11, Iss 11, p 2797 (2019)
Nutrients
Volume 11
Issue 11
ISSN: 2072-6643
Popis: Eggplant (Solanum melongena) is a globally popular vegetable and its significant health effect has not been reported in randomized controlled trials. Recently, we reported that eggplant was rich in choline esters, including acetylcholine (ACh), and had an antihypertensive effect in spontaneously hypertensive rats. Here, we evaluated the effects of a continuous intake of eggplant powder on blood pressure (BP), stress, and psychological state (PS) in 100 stressed participants with normal-high BP or grade 1 hypertension in a randomized, double-blind, placebo-controlled, parallel-group comparative study. The participants were randomly assigned to the eggplant or placebo group. Participants in the eggplant group ingested capsules containing eggplant powder (1.2 g/day
2.3 mg of ACh/day) for 12 weeks, whereas participants in the placebo group ingested placebo capsules. The primary outcome assessed was hospital BP. Secondary outcomes were stress and PS. Eggplant powder intake significantly decreased the hospital diastolic blood pressure (DBP) at week 8 overall and in the normal-high BP group, and the systolic blood pressure (SBP) and DBP at week 12 overall and in the grade 1 hypertension group, compared to those of the placebo group. It also improved negative PSs at week 8 or 12 in the normal-high BP group. This is the first evidence of the BP- and PS-improving effects of eggplant intake in humans. The functional substance responsible for the effects was estimated to be eggplant-derived choline ester, namely ACh.
Databáze: OpenAIRE
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