OF4949, new inhibitors of aminopeptidase B. I Taxonomy, fermentation, isolation and characterization
| Autor: | Yohji Ezure, Hiroyuki Kuroda, Teruya Nakamura, Hiroshi Enomoto, Susumu Sano, Akira Obayashi, Katsushige Ikai |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Chemical Phenomena biology Penicillium Mice Inbred Strains Fungi imperfecti biology.organism_classification Aminopeptidases Peptides Cyclic Aminopeptidase Ehrlich ascites carcinoma Chemistry Mice Aminopeptidase B Enzyme Biochemistry chemistry Delayed hypersensitivity Enzyme inhibitor Fermentation Drug Discovery biology.protein Animals |
| Zdroj: | The Journal of Antibiotics. 39:1674-1684 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.39.1674 |
| Popis: | New aminopeptidase B inhibitors that we named OF4949-I, II, III and IV were isolated from the culture broth of a fungus, Penicillium rugulosum OF4949. The molecular formula of I was C23H26N4O8 and that of II, C22H24O8, judging from elemental analysis and secondary ion mass spectrometry. The concentrations of I, II, III and IV required for 50% inhibition of aminopeptidase, using Ehrlich ascites carcinoma cells as the source of the enzyme, were 0.0054, 0.0048, 3.4 and 1.7 micrograms/ml, respectively. Components I and II augmented delayed-type hypersensitivity in mice to sheep red blood cells. |
| Databáze: | OpenAIRE |
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