Altered perspective-dependent brain activation while viewing hands and associated imitation difficulties in individuals with autism spectrum disorder

Autor: Motohide Miyahara, Norihiro Sadato, Hidehiko Okazawa, Hiroaki Naruse, Yuko Okamoto, Hirotaka Kosaka, Ryo Kitada, Takanori Kochiyama
Přispěvatelé: School of Humanities and Social Sciences
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
genetic structures
Lateral occipito-temporal cortex
Autism Spectrum Disorder
Functional magnetic resonance imaging
Neuropsychological Tests
lcsh:RC346-429
0302 clinical medicine
LOTC
lateral occipito-temporal cortex

Cerebellum
Functional Magnetic Resonance Imaging
Neural Pathways
Prefrontal cortex
media_common
Brain Mapping
Visual self-body recognition
medicine.diagnostic_test
MFG
middle frontal gyrus

ACC
anterior cingulate cortex

05 social sciences
Brain
Regular Article
Magnetic Resonance Imaging
MOG
middle occipital gyrus

IQ
intelligence quotient

Neurology
SRS
social responsiveness scale

Autism spectrum disorder
CMS
cortical midline structure

lcsh:R858-859.7
Imitation
Female
Psychology
IPL
inferior parietal lobule

Adult
ASD
autism spectrum disorder

Cognitive Neuroscience
media_common.quotation_subject
Posture
Affect (psychology)
MNS
mirror neuron system

lcsh:Computer applications to medicine. Medical informatics
behavioral disciplines and activities
050105 experimental psychology
03 medical and health sciences
Young Adult
Perception
mental disorders
medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging

EBA
extrastriate body area

IOG
inferior occipital gyrus

lcsh:Neurology. Diseases of the nervous system
DISCO
diagnostic Interview for Social and communication Disorders

Perspective (graphical)
mPFC
medial prefrontal cortex

Inferior parietal lobule
AQ
autism spectrum quotient

medicine.disease
Hand
FISQ
full-scale intelligence quotient

Neurology (clinical)
ULS
upper limb sensitive

Neuroscience
TD
typically developing

030217 neurology & neurosurgery
Zdroj: NeuroImage: Clinical, Vol 19, Iss, Pp 384-395 (2018)
NeuroImage : Clinical
ISSN: 2213-1582
Popis: Background Individuals with autism spectrum disorder (ASD) appear to have a unique awareness of their own body, which may be associated with difficulties of gestural interaction. In typically developing (TD) individuals, the perception of body parts is processed in various brain regions. For instance, activation of the lateral occipito-temporal cortex (LOTC) is known to depend on perspective (i.e., first- or third-person perspective) and identity (i.e., own vs. another person's body). In the present study, we examined how perspective and identity affect brain activation in individuals with ASD, and how perspective- and identity-dependent brain activation is associated with gestural imitation abilities. Methods Eighteen young adults with ASD and 18 TD individuals participated in an fMRI study in which the participants observed their own or another person's hands from the first- and third-person perspectives. We examined whether the brain activation associated with perspective and identity was altered in individuals with ASD. Furthermore, we identified the brain regions the activity of which correlated with gestural imitation difficulties in individuals with ASD. Results In the TD group, the left LOTC was more strongly activated by viewing a hand from the third-person perspective compared with the first-person perspective. This perspective effect in the left LOTC was significantly attenuated in the ASD group. We also observed significant group differences in the perspective effect in the medial prefrontal cortex (mPFC). Correlation analysis revealed that the perspective effect in the inferior parietal lobule (IPL) and cerebellum was associated with the gestural imitation ability in individuals with ASD. Conclusions Our study suggests that atypical visual self-body recognition in individuals with ASD is associated with an altered perspective effect in the LOTC and mPFC, which are thought to be involved in the physical and core selves, respectively. Furthermore, the gestural imitation difficulty in individuals with ASD might be associated with the altered activation in the IPL and cerebellum, but not in the LOTC. These findings shed light on common and divergent neural mechanisms underlying atypical visual self-body awareness and gestural interaction in ASD.
Highlights • Own-body awareness and gestural skills are altered in autism spectrum disorder (ASD). • The lateral occipito-temporal cortex (LOTC) is key for body perspective and identity. • The perspective effects in the LOTC and medial prefrontal cortex are altered in ASD. • Inferior parietal lobule and cerebellum activity underlie imitation deficits in ASD. • Identity and perspective dysperception may alter the body-gesture interaction in ASD.
Databáze: OpenAIRE