Sex differences in vectorcardiogram of African-Americans with and without cardiovascular disease: a cross-sectional study in the Jackson Heart Study cohort
| Autor: | Larisa G. Tereshchenko, Kevin A. Paternostro, Joao A.C. Lima, Solomon K. Musani, Elsayed Z. Soliman, Nichole M. Rogovoy, Kazi T. Haq, James D. Pollard, Joseph F. Maher, Katherine J. Lutz |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Cross-sectional study medicine.medical_treatment lcsh:Medicine Carotid endarterectomy 030204 cardiovascular system & hematology Cardiovascular Medicine Cohort Studies 03 medical and health sciences QRS complex 0302 clinical medicine Mississippi Risk Factors Silent Myocardial Infarction Internal medicine adult cardiology Medicine Humans 030212 general & internal medicine Longitudinal Studies Prospective Studies coronary heart disease Stroke pacing & electrophysiology cardiac epidemiology Sex Characteristics business.industry lcsh:R General Medicine Anthropometry medicine.disease Black or African American Cross-Sectional Studies Cardiovascular Diseases Cohort Cardiology Female business Cohort study |
| Zdroj: | BMJ Open BMJ Open, Vol 11, Iss 1 (2021) |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesWe hypothesised that (1) the prevalent cardiovascular disease (CVD) is associated with global electrical heterogeneity (GEH) after adjustment for demographic, anthropometric, socioeconomic and traditional cardiovascular risk factors, (2) there are sex differences in GEH and (3) sex modifies an association of prevalent CVD with GEH.DesignCross-sectional, cohort study.SettingProspective African-American The Jackson Heart Study (JHS) with a nested family cohort in 2000–2004 enrolled residents of the Jackson, Mississippi metropolitan area.ParticipantsParticipants from the JHS with analysable ECGs recorded in 2009–2013 (n=3679; 62±12 y; 36% men; 863 family units). QRS, T and spatial ventricular gradient (SVG) vectors’ magnitude and direction, spatial QRS-T angle and sum absolute QRST integral (SAI QRST) were measured.OutcomePrevalent CVD was defined as the history of (1) coronary heart disease defined as diagnosed/silent myocardial infarction, or (2) revascularisation procedure defined as prior coronary/peripheral arterial revascularisation, or (3) carotid angioplasty/carotid endarterectomy, or (4) stroke.ResultsIn adjusted mixed linear models, women had a smaller spatial QRS-T angle (−12.2 (95% CI −19.4 to -5.1)°; p=0.001) and SAI QRST (−29.8 (−39.3 to −20.3) mV*ms; pConclusionsThere are sex differences in the electrical signature of CVD in African-American men and women. There is a significant effect of unmeasured genetic and environmental factors on cardiac repolarisation. |
| Databáze: | OpenAIRE |
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