Micronucleus test with procarbazine hydrochloride administered by intraperitoneal injection and oral gavage
| Autor: | Tatsuo Inouye, Shun-ichiro Ishii, Mie Watanabe, Hisako Imanishi, YūF. Sasaki, Nobuaki Ando, Yasuhiko Shirasu |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_treatment Intraperitoneal injection Administration Oral Pilot Projects Pharmacology Toxicology Procarbazine Lethal Dose 50 Mice Clastogen Route of administration Oral administration Genetics medicine Animals Procarbazine Hydrochloride Micronucleus Tests business.industry Acute toxicity Immunology Micronucleus test business Injections Intraperitoneal Mutagens medicine.drug |
| Zdroj: | Mutation Research/Genetic Toxicology. 223:411-414 |
| ISSN: | 0165-1218 |
| DOI: | 10.1016/0165-1218(89)90098-0 |
| Popis: | The difference in effect of route of administration of procarbazine hydrochloride (PCZ) in the mouse was investigated in the micronucleus test. PCZ was administered by intraperitoneal injection (i.p.) and oral administration (p.o.) to 2 strains of male mice (MS/Ae and CD-1). On the basis of a small-scale acute toxicity test and a pilot micronucleus test, bone marrow preparations were prepared 24 h after the administration by the i.p. and p.o. routes of 50–400 mg/kg and 200–1600 mg/kg, respectively. The maximum incidence of polychromatic erythrocytes with micronuclei (MNPCEs) was somewhat higher after p.o. treatment in MS/Ae mice and the same with both routes in CD-1 mice. Thus, the clastogenicity of PCZ in mouse bone marrow was revealed by both routes. |
| Databáze: | OpenAIRE |
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