Immunocytochemical Distribution of VIP and PACAP in the Rat Brain Stem: Implications for REM Sleep Physiology

Autor: Michel Hamon, Michel Arluison, Abdel Ahnaou, Laurent Yon, Joëlle Adrien, Patrice Bourgin, Jens Hannibal, Hubert Vaudry
Přispěvatelé: Neuropsychopharmacologie, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuroendocrinologie cellulaire et moléculaire, Neurobiologie des signaux intercellulaires (NSI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Department of Clinical Biochemistry, Bispebjerg Hospital, Stanford University, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Male
medicine.medical_specialty
dorsal raphe nucleus
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Vasoactive intestinal peptide
Rapid eye movement sleep
Sleep
REM
Adenylate kinase
rapid eye movement sleep
Biology
General Biochemistry
Genetics and Molecular Biology
Rats
Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Dorsal raphe nucleus
History and Philosophy of Science
Internal medicine
ontine reticular formation
medicine
Animals
Distribution (pharmacology)
030304 developmental biology
0303 health sciences
General Neuroscience
Paramedian pontine reticular formation
Sleep in non-human animals
pituitary adenylate cyclase-activating polypeptide
Rats
medicine.anatomical_structure
Endocrinology
immunohistochemistry
Immunohistochemistry
vasoactive intestinal polypeptide
Neuroscience
030217 neurology & neurosurgery
hormones
hormone substitutes
and hormone antagonists
Brain Stem
Vasoactive Intestinal Peptide
Zdroj: Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences, Wiley, 2006, VIP, PACAP, and related peptides: from gene to therapy, 1070 (1), pp.135-142. ⟨10.1196/annals.1317.095⟩
Annals of the New York Academy of Sciences, 2006, VIP, PACAP, and related peptides: from gene to therapy, 1070 (1), pp.135-142. ⟨10.1196/annals.1317.095⟩
ISSN: 0077-8923
1749-6632
DOI: 10.1196/annals.1317.095⟩
Popis: International audience; Recent evidence indicates that pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) might play an important role in rapid eye movement sleep (REMS) generation at the pontine level in rats. We have thus examined the im-munohistochemical distribution of VIP and PACAP in the pontine and mesencephalic areas known to be involved in REMS control in rats. A dense network of VIP-immunoreactive cell bodies and fibers was found in the dorsal raphe nucleus. A large number of PACAP-positive perikarya and nerve fibers was observed in the area known as the REMS induction zone within the pontine reticular formation (PRF). The present results provide an anatomical basis to our previous functional data, and suggest that PACAPergic mechanisms within the PRF play a critical role in long-term regulation of REMS.
Databáze: OpenAIRE
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