| Autor: |
Dianita Primihastuti, Dyah Woro Kartiko Kusumo Wardani, Yuningsih, Primaditya, Vanda, Fitra Arsy Nur Cory'ah, Ariati, Linda Ika Puspita, Zakiah, Umi Kalsum, Husnul Khotimah, Ali, Mohammad Mulyohadi, Wibi Riawan |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
GSC Biological and Pharmaceutical Sciences. 19:091-099 |
| ISSN: |
2581-3250 |
| DOI: |
10.30574/gscbps.2022.19.1.0130 |
| Popis: |
Stunting, according to the WHO, is defined as body length or body height with respect to the same age that is less than minus two standard deviations (Centella asiaticaor pegagan is a plant that has antioxidant effects. Zebrafish embryos were treated with pegagan at concentrations of 1.25, 2.5, and 5 µg/ml. Exposure to treatments began from 2 to 72 hpf and development was monitored until the larval age of 9 dpf. Rotenone at a concentration of 12.5 ppb can inducestunting. There was a decrease in the process of bone ossification and an increase in the expression of RANKL in zebrafish larvae induced by rotenone. Meanwhile, the extract ofCentella asiaticaat concentrations of 2.5 µg/ml and 5 µg/ml was able to increase body length. Pegagan 5 µg/m shown the most significant effect for the increase in bone ossification (p Centella asiaticaextract treatment groups from the lowest concentration 1.25 µg/ml, up to 2.5 µg/ml and 5 µg/ml.Centella asiaticaextract of 2.5 µg/ml and 5 µg/ml concentrations can increase the body length of zebrafish larvae, increase bone ossification, and lower the expression of RANKL, which has an effect on the process of osteoclastogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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