Physician and patient perceptions of fecal microbiota transplant for recurrent or refractory Clostridioides difficile in the first 6 years of a central stool bank
| Autor: | Lito E. Papanicolas, Karmen Telfer, Charlotte Blacketer, Lisa M Dann, Samuel P Costello, Madeleine Gill, Franco Chitti, Emily C. Tucker, Robert V Bryant |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
physician Hepatology Referral Clostridioides difficile business.industry Gastroenterology fecal microbiota transplantation RC799-869 Fecal bacteriotherapy perception Diseases of the digestive system. Gastroenterology Patient perceptions Refractory stool bank Internal medicine Patient experience medicine Infectious disease (athletes) business Disease transmission Clostridioides |
| Zdroj: | JGH Open, Vol 4, Iss 5, Pp 950-957 (2020) |
| ISSN: | 2397-9070 |
| DOI: | 10.1002/jgh3.12396 |
| Popis: | Background and Aim Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent or refractory Clostridioides difficile infection (rCDI). Despite inclusion in society guidelines, the uptake of FMT therapy has been variable. Physician and patient attitudes may be a barrier to evidence‐based uptake of therapies; however, data assessing attitudes regarding FMT for rCDI are limited. Methods The South Australian FMT for CDI database prospectively recorded patient outcomes of FMT for CDI from August 2013 to January 2019. A total of 93 consecutive patients who underwent FMT for rCDI in South Australia were invited to participate in a 20‐question survey regarding the patient experience of FMT. All gastroenterologists and infectious disease physicians practicing in South Australia were invited to participate in an online survey comprised of 22 questions that addressed referral experience, indications for referral, perceived risks, and regulation and funding. Results Fifty‐four patients (54/93, 58%) returned the survey, of whom 52 (96%) would recommend FMT to others, and 51 (94%) were satisfied with treatment outcome. Fifty physicians returned the online survey (50/100, 50%), of whom 23 (46%) were concerned about disease transmission risk, and 15 (30%) believed that the risk of FMT would outweigh the benefit. Infectious diseases physicians and advanced trainees had significantly greater concern regarding the potential alteration of the microbiome than gastroenterology physicians and advanced trainees (8/17 (47%) vs 6/33 (18%); P = 0.047). Conclusion Despite high levels of patient‐reported satisfaction following FMT, physician‐reported reservations exist and may present a barrier to uptake of this therapy. |
| Databáze: | OpenAIRE |
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