Contactin1a expression is associated with oligodendrocyte differentiation and axonal regeneration in the central nervous system of zebrafish
| Autor: | Melitta Schachner, Bettina C Lieberoth, Hans-Martin Pogoda, Jörn Schweitzer, Thomas Becker, Anselm Ebert, Catherina G. Becker, Julia Feldner, Dimitrios Gimnopoulos |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Central Nervous System
Embryo Nonmammalian Receptor ErbB-3 Cell Adhesion Molecules Neuronal Central nervous system Retinal ganglion Eye Enucleation Animals Genetically Modified Cellular and Molecular Neuroscience Myelin Microscopy Electron Transmission Contactin 1 Contactins medicine Animals RNA Messenger Molecular Biology Zebrafish In Situ Hybridization Spinal Cord Injuries Neurons biology Oligodendrocyte differentiation Gene Expression Regulation Developmental Cell Differentiation Cell Biology Zebrafish Proteins Spinal cord biology.organism_classification Nerve Regeneration Cell biology Myelin-Associated Glycoprotein Oligodendroglia medicine.anatomical_structure Animals Newborn nervous system Optic Nerve Injuries Optic nerve Schwann cell differentiation Myelin P0 Protein Neuroscience |
| Zdroj: | Molecular and Cellular Neuroscience. 35:194-207 |
| ISSN: | 1044-7431 |
| DOI: | 10.1016/j.mcn.2007.02.018 |
| Popis: | Contactin1a (Cntn1a) is a zebrafish homolog of contactin1 (F3/F11/contactin) in mammals, an immunoglobulin superfamily recognition molecule of neurons and oligodendrocytes. We describe conspicuous Cntn1a mRNA expression in oligodendrocytes in the developing optic pathway of zebrafish. In adults, this expression is only retained in glial cells in the intraretinal optic fiber layer, which contains 'loose' myelin. After optic nerve lesion, oligodendrocytes re-express Cntn1a mRNA independently of the presence of regenerating axons and retinal ganglion cells upregulate Cntn1a expression to levels that are significantly higher than those during development. After spinal cord lesion, expression of Cntn1a mRNA is similarly increased in axotomized brainstem neurons and white matter glial cells in the spinal cord. In addition, reduced mRNA expression in the trigeminal/anterior lateral line ganglion in erbb3-deficient mutant larvae implies Cntn1a in Schwann cell differentiation. These complex regulation patterns suggest roles for Cntn1a in myelinating cells and neurons particularly in successful CNS regeneration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect