Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway
| Autor: | Jian-mei Gao, Xun Zhang, Guo-tao Shu, Na-na Chen, Jian-yong Zhang, Fan Xu, Fei Li, Yuan-gui Liu, Yu Wei, Yu-qi He, Jing-shan Shi, Qi-hai Gong |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Flavonoids Amyloid beta-Peptides Superoxide Dismutase NF-kappa B Polyphenols Mice Transgenic General Medicine Rats Molecular Docking Simulation Toll-Like Receptor 4 Disease Models Animal Mice Neuroprotective Agents Alzheimer Disease Sirtuin 3 Animals Pharmacology (medical) Cognitive Dysfunction Food Additives HMGB1 Protein Signal Transduction |
| Zdroj: | Acta pharmacologica Sinica. 43(10) |
| ISSN: | 1745-7254 |
| Popis: | Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive impairment that currently is uncurable. Previous study shows that trilobatin (TLB), a naturally occurring food additive, exerts neuroprotective effect in experimental models of AD. In the present study we investigated the molecular mechanisms underlying the beneficial effect of TLB on experimental models of AD in vivo and in vitro. APP/PS1 transgenic mice were administered TLB (4, 8 mg· kg |
| Databáze: | OpenAIRE |
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