Childhood sleep duration modifies the polygenic risk for obesity in youth through leptin pathway: the Beijing Child and Adolescent Metabolic Syndrome cohort study
| Autor: | Yu Li, Dan Feng, Junling Fu, Lanwen Han, Shan Gao, Struan F.A. Grant, Xinhua Xiao, Lujiao Li, Yunpeng Wu, Ming Li, Mingyao Li, Yonghui Wang, Ge Li |
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| Rok vydání: | 2019 |
| Předmět: |
Leptin
Male China Multifactorial Inheritance Pediatric Obesity Pediatrics medicine.medical_specialty Time Factors Adolescent Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism Overweight Article Childhood obesity Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Genetic predisposition Humans Genetic Predisposition to Disease Obesity 030212 general & internal medicine Child Metabolic Syndrome 2. Zero hunger Nutrition and Dietetics business.industry medicine.disease Female Gene-Environment Interaction medicine.symptom Metabolic syndrome Sleep business Body mass index Follow-Up Studies Cohort study |
| Zdroj: | International Journal of Obesity (2005) |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/s41366-019-0405-1 |
| Popis: | Background/objectives Short sleep is an obesity risk factor, however, little is known about its interplay with genetic predisposition and pathways involved in obesity pathogenesis, especially in the longitudinal setting. We aimed to investigate a possible sleep-gene interaction for childhood obesity risk, and whether the interaction in childhood longitudinally contributes to obesity risk at a 10-year follow-up and further to test if there is any mediation through the leptin pathway. Subjects/methods A total of 3211 children from China (6–18 years) at baseline and 848 participants at 10-year follow-up from the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) cohort study were analyzed. Baseline leptin concentrations and 12 established adult body mass index (BMI) loci were examined for the associations with habitual sleep duration. Results After adjusting for covariates, including pubertal stages and behavioral factors, short sleep duration at baseline was significantly associated with increased overweight/obesity risk at both baseline and follow-up. Genetic predisposition scores (GPS), particularly consisting of leptin-related SNPs (GPSleptin), were robustly associated with baseline overweight/obesity in children who slept ≤8 h/day (P 0.05). Comparable observations were made at follow-up. Mediation analysis revealed a modest direct effect of the GPSleptin-sleep interaction on BMI at baseline, while a significant indirect effect of this interaction was found to be mediated principally through elevated leptin (proportion: 52.6%); moreover, the mediation effect via leptin remained stable over 10 years. Conclusions This study suggests that shorter sleep duration in children from China ( |
| Databáze: | OpenAIRE |
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