Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers
| Autor: | Ishak Ozel Tekin, Asuman Karakaya, Ilker Ates, H. Sinan Suzen, Berran Yucesoy |
|---|---|
| Přispěvatelé: | Zonguldak Bülent Ecevit Üniversitesi |
| Rok vydání: | 2008 |
| Předmět: |
Time Factors
Genotype medicine.medical_treatment Polymerase Chain Reaction Severity of Illness Index Risk Factors Severity of illness Humans Medicine Genetic Predisposition to Disease Interleukin 6 Genotyping Polymorphism Genetic biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Pneumoconiosis Public Health Environmental and Occupational Health Middle Aged Occupational exposure Coal workers' pneumoconiosis medicine.disease Coal Mining Cytokine gene polymorphisms Coal Cytokine IL1A Turkish coal workers Immunology biology.protein Cytokines Gene polymorphism business human activities Polymorphism Restriction Fragment Length |
| Zdroj: | American Journal of Industrial Medicine. 51:741-747 |
| ISSN: | 1097-0274 0271-3586 |
| Popis: | Background: Cytokines appear to play a key role in some inflammatory reactions affecting the interactions among pro- and anti-inflammatory mechanisms that result in several diseases such as coal workers' pneumoconiosis (CWP). In this study, to determine the cytokine gene profiles of Turkish coal miners, we performed genotyping analysis to investigate the polymorphisms of CWP-related pro-inflammatory (TNFA, IL1A, IL1B, and IL6) and anti-inflammatory cytokines (IL-1RN and TGFB1). An additional goal was to observe whether these cytokine gene polymorphisms influence the development risk and severity of. Methods: Genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results: TNFA (-238) gene polymorphism principally affected CWP development and severity (OR = 3.47: 95% CI, 1.12-10.77 and OR = 4.30: 95% CI, 1.25-14.74, respectively) and also risk of CWP (OR = 3.79: 95% CI, 1.37-10.46). The TNFA (-308) variant was associated with a risk for the CWP severity (OR = 2.84: 95% CI, 1.08-7.39). A protective effect of IL6 was found on the development (OR = 0.48: 95% CI, 0.21-0.93) and severity of CWP (OR = 0.37: 95% CI, 0.15-0.91). Conclusions: We suggest that TNFA (-238) variant may be a risk factor in both development and the severity of CWP, while TNFA (-308) variant seems to be important only in disease severity. On the other hand, IL6 variant may have a protective effect on the development and disease severity. © 2008 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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